Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 7/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 3/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2219801 | 0.95 | IRAK1 (0.33) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL2219314 | 0.93 | CCR5 (0.34) | KDRCCR5HTR7OPRM1 | |
| SCHEMBL2274437 | 0.90 | CCR5 (0.34) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL2222897 | 0.90 | SMN1; SMN2 (0.36) | CCR5 | |
| SCHEMBL13275685 | 0.89 | OPRM1 (0.33) | ENPP2OPRM1 | |
| SCHEMBL2362780 | 0.88 | OPRM1 (0.36) | HTR7ENPP2OPRM1 | |
| SCHEMBL13507143 | 0.86 | ENPP2 (0.33) | ENPP2 | |
| SCHEMBL2221804 | 0.85 | ENPP2 (0.35) | FGFR1FGFR3ENPP2 | |
| SCHEMBL2272785 | 0.85 | ENPP2 (0.35) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL13275099 | 0.85 | CASR (0.36) | OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2515657-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |