Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 6/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2219314 | 0.95 | CCR5 (0.34) | OPRM1PARP1CACNA2D1HTR7 | |
| SCHEMBL13275685 | 0.93 | OPRM1 (0.33) | OPRM1SIGMAR1ENPP2MEN1KMT2A | |
| SCHEMBL2219801 | 0.93 | IRAK1 (0.33) | OPRM1SIGMAR1ENPP2MEN1KMT2A | |
| SCHEMBL13274713 | 0.92 | FGFR1 (0.34) | OPRM1SIGMAR1PARP1ENPP2MEN1 | |
| SCHEMBL13275099 | 0.92 | CASR (0.36) | OPRM1SIGMAR1PARP1MCHR1 | |
| SCHEMBL2221804 | 0.89 | ENPP2 (0.35) | PARP1ENPP2CACNA2D1MEN1KMT2A | |
| SCHEMBL2272785 | 0.89 | ENPP2 (0.35) | PARP1ENPP2CACNA2D1MEN1KMT2A | |
| SCHEMBL2265615 | 0.88 | FGFR1 (0.35) | OPRM1ENPP2HTR7 | |
| SCHEMBL2334239 | 0.88 | ENPP2 (0.34) | ENPP2CACNA2D1MEN1KMT2A | |
| SCHEMBL2362163 | 0.88 | OPRM1 (0.36) | OPRM1SIGMAR1PARP1MAPK14CACNA2D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2515657-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-31 | — | — | EP | claimed |
| US-20120264735-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2012-10-18 | — | — | US | claimed |
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | claimed |
| US-20140165873-A1 | Phenylcyclohexanol Derivatives As Wax Modifiers And Gelators | XEROX CORPORATION (US) | 2014-06-19 | — | — | US | disclosed |
| EP-2515657-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264735-A1 | TYROSINE KINASE INHIBITORS | ABL1, MET, ERBB2 | OPRM1 2711/4885SIGMAR1 3491/4885PARP1 2307/4885 |
| US-20140165873-A1 | Phenylcyclohexanol Derivatives As Wax Modifiers And Gelators | NR1H3, RXRG, NR1H2 | OPRM1 610/4885SIGMAR1 235/4885PARP1 2572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.