Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | HBB | P68871 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.34 |
| ▸ | NT5E | P21589 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22110554 | 1.00 | LMNA (0.43) | LMNAMAPTESR1SMN1; SMN2TSHR | |
| SCHEMBL20879429 | 0.88 | ALDH1A1 (0.43) | SMN1; SMN2P2RY6 | |
| SCHEMBL12060749 | 0.79 | LMNA (0.53) | LMNAMAPTESR1SMN1; SMN2TSHR | |
| SCHEMBL26284249 | 0.78 | LMNA (0.46) | LMNAMAPTESR1SMN1; SMN2TSHR | |
| SCHEMBL26804160 | 0.78 | LMNA (0.46) | LMNAMAPTESR1SMN1; SMN2TSHR | |
| SCHEMBL17533853 | 0.78 | LMNA (0.41) | LMNAMAPTESR1SMN1; SMN2TSHR | |
| SCHEMBL30590087 | 0.74 | LMNA (0.40) | LMNAMAPTESR1SMN1; SMN2TSHR | |
| SCHEMBL20879499 | 0.73 | TK1 (0.47) | LMNATSHRPMP22 | |
| SCHEMBL31652974 | 0.73 | LMNA (0.51) | LMNAMAPTESR1SMN1; SMN2TSHR | |
| SCHEMBL20879548 | 0.73 | LMNA (0.42) | LMNAMAPTESR1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3738969-A1 | 2'-CHLORO AMINOPYRIMIDINONE AND PYRIMIDINE DIONE NUCLEOSIDES FOR USE IN TREATING PNEUMOVIRINAE VIRUS INFECTIONS | Gilead Sciences, Inc. (US) | 2020-11-18 | — | — | EP | disclosed |