Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10153310 | 0.77 | NR4A2 (0.47) | ALDH1A1L3MBTL1NR4A2GAAMAPT | |
| SCHEMBL2608522 | 0.76 | ALDH1A1 (0.38) | ALDH1A1HDAC1HDAC6LPAR1KDM4E | |
| SCHEMBL395221 | 0.74 | ALDH1A1 (0.64) | ALDH1A1KDM4EMAPK1MAPTRAB9A | |
| SCHEMBL30558592 | 0.74 | ALDH1A1 (0.64) | ALDH1A1KDM4EMAPK1MAPTRAB9A | |
| SCHEMBL9942862 | 0.71 | ABCG2 (0.52) | ALDH1A1L3MBTL1KDM4ENR4A2MAPK1 | |
| SCHEMBL23606883 | 0.71 | MEN1 (0.40) | ALDH1A1HDAC1HDAC6MEN1KMT2A | |
| SCHEMBL30443727 | 0.71 | ALDH1A1 (0.64) | ALDH1A1KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL1478090 | 0.70 | MT-CO2 (0.42) | ALDH1A1LPAR1KDM4EMEN1KMT2A | |
| SCHEMBL999785 | 0.70 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL15300893 | 0.69 | ALDH1A1 (0.42) | ALDH1A1LPAR1L3MBTL1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11160797-B2 | Pyridinone derivatives and their use as selective ALK-2 inhibitors | NOVARTIS AG (CH) | 2021-11-02 | — | — | US | disclosed |
| US-20200360357-A1 | Pyridinone derivatives and their use as selective ALK-2 inhibitors | NOVARTIS AG (CH) | 2020-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200360357-A1 | Pyridinone derivatives and their use as selective ALK-2 inhibitors | ALK, ACVR2B, ACVR1B | ALDH1A1 118/4885HDAC1 3909/4885HDAC6 3268/4885 |
| US-11160797-B2 | Pyridinone derivatives and their use as selective ALK-2 inhibitors | ALK, ACVR2B, ACVR1B | ALDH1A1 118/4885HDAC1 3909/4885HDAC6 3268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.