Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | DGKA | P23743 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PRKCA | P17252 | 3/20 | 0.42 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.42 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL7037542 | 0.94 | MAPT (0.46) | MAPTDGKAKDM4EDUSP3MEN1 | |
| Propylene Glycol SCHEMBL10781715 | 0.90 | MAPT (0.61) | MAPTDGKAKDM4EDUSP3MEN1 | |
| Propylene Glycol SCHEMBL443947 | 0.89 | NAAA (0.55) | MAPTDGKAKDM4EDUSP3MEN1 | |
| Propylene Glycol SCHEMBL10559512 | 0.88 | MAPT (0.51) | MAPTDGKAKDM4EDUSP3MEN1 | |
| Propylene Glycol SCHEMBL3734196 | 0.87 | MAPT (0.53) | MAPTDGKAKDM4EDUSP3MEN1 | |
| Propylene Glycol SCHEMBL28657913 | 0.83 | MAPT (0.67) | MAPTDGKAKDM4EDUSP3MEN1 | |
| Cetyl Palmitate SCHEMBL8103871 | 0.83 | MAPT (0.67) | MAPTDGKAKDM4EDUSP3MEN1 | |
| Acetic Acid Butyl Ester SCHEMBL107642 | 0.83 | ALDH1A1 (0.62) | MAPTLMNAALDH1A1 | |
| Propylene Glycol SCHEMBL8961545 | 0.83 | NAAA (0.66) | MAPTDGKAKDM4EDUSP3MEN1 | |
| Propylene Glycol SCHEMBL18393480 | 0.82 | MAPT (0.47) | MAPTDGKAKDM4EDUSP3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8741809-B2 | Liquid pyraclostrobin-containing crop protection formulations | BASF SE (DE) | 2014-06-03 | — | — | US | disclosed |
| US-20110195846-A1 | Liquid Pyraclostrobin-Containing Crop Protection Formulations | BASF SE (DE) | 2011-08-11 | — | — | US | disclosed |