Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | DGKA | P23743 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL443947 | 0.94 | NAAA (0.55) | NAAAMAPTRAD52NPSR1DGKA | |
| Propylene Glycol SCHEMBL10559512 | 0.89 | MAPT (0.51) | NAAAMAPTRAD52NPSR1FAAH | |
| Ether SCHEMBL38599 | 0.88 | NAAA (0.84) | NAAARAD52NPSR1FAAHDGKA | |
| Propylene Glycol SCHEMBL445696 | 0.87 | NAAA (0.44) | NAAAMAPTUSP2DGKAKDM4E | |
| Propylene Glycol SCHEMBL5144291 | 0.87 | NAAA (0.62) | NAAAMAPTRAD52NPSR1DGKA | |
| Hexyl Acetate SCHEMBL896029 | 0.86 | ALDH1A1 (0.53) | NAAAMAPTUSP2KDM4EDUSP3 | |
| Tetradecylacetate SCHEMBL466058 | 0.86 | ALDH1A1 (0.53) | NAAAMAPTUSP2KDM4EDUSP3 | |
| Ether SCHEMBL2254830 | 0.85 | NAAA (0.71) | NAAAMAPTRAD52NPSR1FAAH | |
| Acetic Acid Pentyl Ester SCHEMBL2269446 | 0.84 | ALDH1A1 (0.55) | NAAAMAPTUSP2KDM4EDUSP3 | |
| Propylene Glycol SCHEMBL2266764 | 0.83 | MAPT (0.50) | NAAAMAPTDGKAKDM4EDUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5525346-A | BLEND OF A POLYDIMETHYLKSILOXANE AND NONIONIC EMULSIFIER | ABBOTT LABORATORIES (US) | 1996-06-11 | — | — | US | claimed |