Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.48 |
| ▸ | ACACB | O00763 | 4/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22680899 | 0.81 | ACACB (0.47) | HSD11B1ACACBHRH3KDM4EALDH1A1 | |
| SCHEMBL21261031 | 0.81 | ADRB1 (0.40) | ACACBKDM4EALDH1A1GRM2MAPT | |
| SCHEMBL26796037 | 0.74 | HSD11B1 (0.41) | HSD11B1ACACBHRH3KDM4EALDH1A1 | |
| SCHEMBL19001019 | 0.73 | HSD11B1 (0.41) | HSD11B1ACACBHRH3MAPTNPC1 | |
| SCHEMBL26802563 | 0.73 | ACACB (0.43) | HSD11B1ACACBHRH3KDM4EALDH1A1 | |
| SCHEMBL25900775 | 0.72 | ACACB (0.38) | HSD11B1ACACBHRH3 | |
| SCHEMBL19001086 | 0.72 | CYP2C9 (0.43) | HSD11B1ACACBKDM4EALDH1A1HTT | |
| SCHEMBL19001087 | 0.72 | CYP2C9 (0.43) | HSD11B1ACACBKDM4EALDH1A1HTT | |
| SCHEMBL19001144 | 0.72 | CYP2C9 (0.43) | HSD11B1ACACBKDM4EALDH1A1HTT | |
| SCHEMBL19001104 | 0.72 | POLB (0.45) | HSD11B1ACACBHRH3MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840527-B2 | Non-fused thiophene derivatives and their uses | ENYO PHARMA (FR) | 2023-12-12 | — | — | US | disclosed |
| US-11840527-B2 | Non-fused thiophene derivatives and their uses | ENYO PHARMA (FR) | 2023-12-12 | — | — | US | disclosed |
| US-20200369655-A1 | NON-FUSED THIOPHENE DERIVATIVES AND THEIR USES | ENYO PHARMA (FR) | 2020-11-26 | — | — | US | disclosed |
| US-20200361924-A1 | FUSED THIOPHENE DERIVATIVES AND THEIR USES | ENYO PHARMA (FR) | 2020-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200361924-A1 | FUSED THIOPHENE DERIVATIVES AND THEIR USES | FTH1, SLC40A1, FECH | HSD11B1 2917/4885ACACB 531/4885HRH3 4290/4885 |
| US-20200369655-A1 | NON-FUSED THIOPHENE DERIVATIVES AND THEIR USES | FTH1, SLC40A1, FECH | HSD11B1 3152/4885ACACB 771/4885HRH3 4237/4885 |
| US-11840527-B2 | Non-fused thiophene derivatives and their uses | FTH1, SLC40A1, FECH | HSD11B1 3152/4885ACACB 771/4885HRH3 4237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.