Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.41 |
| ▸ | ACACB | O00763 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19001104 | 0.92 | POLB (0.45) | HSD11B1ACACBTSHRHRH3SIGMAR1 | |
| SCHEMBL19000981 | 0.92 | POLB (0.45) | HSD11B1ACACBTSHRHRH3SIGMAR1 | |
| SCHEMBL19000960 | 0.92 | POLB (0.45) | HSD11B1ACACBTSHRHRH3SIGMAR1 | |
| SCHEMBL19001103 | 0.92 | POLB (0.45) | HSD11B1ACACBTSHRHRH3SIGMAR1 | |
| SCHEMBL26796015 | 0.85 | SIGMAR1 (0.45) | HSD11B1HRH3SIGMAR1NPC1MAPK1 | |
| SCHEMBL1470433 | 0.84 | HSD11B1 (0.41) | HSD11B1ACACBTSHRHRH3NPC1 | |
| SCHEMBL1470434 | 0.84 | HSD11B1 (0.41) | HSD11B1ACACBTSHRHRH3NPC1 | |
| SCHEMBL23328245 | 0.82 | HSD11B1 (0.44) | HSD11B1ACACBTSHRHRH3SIGMAR1 | |
| SCHEMBL19001078 | 0.82 | HSD11B1 (0.44) | HSD11B1ACACBTSHRHRH3SIGMAR1 | |
| SCHEMBL19012391 | 0.82 | MAPT (0.53) | HSD11B1ACACBTSHRSIGMAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840527-B2 | Non-fused thiophene derivatives and their uses | ENYO PHARMA (FR) | 2023-12-12 | — | — | US | disclosed |
| US-20230382909-A1 | BICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2023-11-30 | — | — | US | disclosed |
| US-20230374008-A1 | BICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2023-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230382909-A1 | BICYCLIC COMPOUNDS | SLC10A1, PKD1, CYP11B2 | HSD11B1 76/4885ACACB 551/4885TSHR 3288/4885 |
| US-20230374008-A1 | BICYCLIC COMPOUNDS | SLC10A1, PKD1, CYP11B2 | HSD11B1 76/4885ACACB 551/4885TSHR 3288/4885 |
| US-11840527-B2 | Non-fused thiophene derivatives and their uses | FTH1, SLC40A1, FECH | HSD11B1 3152/4885ACACB 771/4885TSHR 1240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.