Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17665015 | 0.81 | ADRB1 (0.48) | MAPTALDH1A1RORCMAPK1NPC1 | |
| SCHEMBL24124025 | 0.80 | HSD11B1 (0.41) | MAPTLMNAHSD11B1ALDH1A1MAPK1 | |
| SCHEMBL16437268 | 0.79 | MAPT (0.45) | MAPTLMNAPRKDCHSD11B1ALDH1A1 | |
| SCHEMBL24123997 | 0.79 | CYP2D6 (0.63) | HSD11B1ALDH1A1SMN1; SMN2MAPK1USP2 | |
| SCHEMBL270272 | 0.78 | MAPT (0.65) | MAPTLMNAPRKDCHSD11B1ALDH1A1 | |
| SCHEMBL20178041 | 0.78 | HSD11B1 (0.57) | MAPTLMNAPRKDCHSD11B1ALDH1A1 | |
| SCHEMBL25018482 | 0.78 | LRRK2 (0.46) | MAPTLMNAPRKDCHSD11B1ALDH1A1 | |
| SCHEMBL15400584 | 0.77 | AKR1C3 (0.46) | MAPTLMNAALDH1A1RORCMAPK1 | |
| SCHEMBL14320393 | 0.77 | MAPT (0.50) | MAPTLMNAALDH1A1SMN1; SMN2RORC | |
| SCHEMBL4403156 | 0.77 | HSD11B1 (0.47) | MAPTLMNAPRKDCHSD11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200361924-A1 | FUSED THIOPHENE DERIVATIVES AND THEIR USES | ENYO PHARMA (FR) | 2020-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200361924-A1 | FUSED THIOPHENE DERIVATIVES AND THEIR USES | FTH1, SLC40A1, FECH | MAPT 2107/4885LMNA 4703/4885PRKDC 4615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.