SCHEMBL270272

SCHEMBL270272

CC(C)(C)c1ccc(N2CCOCC2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.65
LMNA P02545 4/20 0.65
PRKDC P78527 3/20 0.59
ALDH1A1 P00352 7/20 0.56
SMN1; SMN2 Q16637 3/20 0.56
HTT P42858 3/20 0.55
MEN1 O00255 3/20 0.55
KMT2A Q03164 3/20 0.55
KDM4E B2RXH2 3/20 0.55
ALOX15 P16050 2/20 0.55
HSD17B10 Q99714 2/20 0.55
USP2 O75604 1/20 0.55
TP53 P04637 1/20 0.55
MAPK1 P28482 1/20 0.55
RAB9A P51151 4/20 0.52
NPC1 O15118 3/20 0.52
CYP1A2 P05177 1/20 0.52
SIGMAR1 Q99720 1/20 0.51
NPSR1 Q6W5P4 1/20 0.50
HPGD P15428 4/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16000561 0.98 MAPT (0.63) MAPTLMNAPRKDCALDH1A1SMN1; SMN2
SCHEMBL22904717 0.89 MEN1 (0.58) MAPTLMNAPRKDCALDH1A1SMN1; SMN2
SCHEMBL20178041 0.87 HSD11B1 (0.57) MAPTLMNAPRKDCALDH1A1HTT
SCHEMBL28295817 0.84 MAPT (0.52) MAPTLMNAPRKDCALDH1A1SMN1; SMN2
SCHEMBL5738297 0.84 MAPT (0.54) MAPTLMNAPRKDCALDH1A1SMN1; SMN2
SCHEMBL14614585 0.84 MAPT (0.52) MAPTLMNAPRKDCALDH1A1SMN1; SMN2
SCHEMBL1453639 0.84 MAPT (0.59) MAPTLMNAPRKDCALDH1A1SMN1; SMN2
SCHEMBL12744643 0.83 L3MBTL3 (0.54) MAPTLMNAPRKDCALDH1A1SMN1; SMN2
SCHEMBL13511002 0.83 PRKDC (0.52) MAPTLMNAPRKDCALDH1A1SMN1; SMN2
SCHEMBL23172976 0.83 HSD11B1 (0.50) MAPTLMNAPRKDCALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 431 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230382909-A1 BICYCLIC COMPOUNDS ALIGOS THERAPEUTICS, INC. 2023-11-30 US disclosed
US-20230374008-A1 BICYCLIC COMPOUNDS ALIGOS THERAPEUTICS, INC. 2023-11-23 US disclosed
EP-4279991-A1 NOVEL SULFONIUM SALT, RESIST COMPOSITION, AND PATTERNING PROCESS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2023-11-22 EP disclosed
US-11814391-B2 Macrocyclic compounds for the treatment of medical disorders ACHILLION PHARMACEUTICALS, INC. (US) 2023-11-14 US disclosed
US-20230357199-A1 ARYL, HETEROARYL, AND HETEROCYCLIC PHARMACEUTICAL COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS ACHILLION PHARMACEUTICALS, INC. 2023-11-09 US disclosed
US-20230357199-A1 ARYL, HETEROARYL, AND HETEROCYCLIC PHARMACEUTICAL COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS ACHILLION PHARMACEUTICALS, INC. 2023-11-09 US disclosed
US-11807641-B2 MASP-2 inhibitors and methods of use OMEROS CORPORATION (US) 2023-11-07 US disclosed
US-11807641-B2 MASP-2 inhibitors and methods of use OMEROS CORPORATION (US) 2023-11-07 US disclosed
US-20230303570-A1 KINASE INHIBITORS AND USES THEREOF ABM THERAPEUTICS CORP (US) 2023-09-28 US disclosed
US-20230303570-A1 KINASE INHIBITORS AND USES THEREOF ABM THERAPEUTICS CORP (US) 2023-09-28 US disclosed
EP-1354887-A1 Ligands for metals and improved metal-catalyzed processes based thereon Massachusetts Insitute of Technology (US) 2003-10-22 EP disclosed
WO-2003066570-A1 TRANSITION-METAL-CATALYZED CARBON-NITROGEN BOND-FORMING METHODS USING CARBENE LIGANDS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2003-08-14 WO disclosed
EP-1313560-A1 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION YALE UNIVERSITY (US) 2003-05-28 EP disclosed
US-6562989-B2 Bicyclopentyl iron ligand and transition metal catalyst YALE UNIVERSITY 2003-05-13 US disclosed
US-20030008768-A1 Catalyst for aromatic C-O, C-N, and C-C bond formation NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2003-01-09 US disclosed
WO-2002011883-A1 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION YALE UNIVERSITY (US) 2002-02-14 WO disclosed
EP-1097158-A2 LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2001-05-09 EP disclosed
WO-2000002887-A2 LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2000-01-20 WO disclosed
EP-0324791-A1 ARYL-N-AMINOALKYL-4-(SULFONAMIDO)BENZAMIDES, ANTIARRHYTMIC AGENTS AND COMPOSITIONS THEREOF. SCHERING AG (DE) 1989-07-26 EP disclosed
WO-1988002362-A1 ARYL-N-AMINOALKYL-4-(SULFONAMIDO)BENZAMIDES, ANTIARRHYTMIC AGENTS AND COMPOSITIONS THEREOF SCHERING AKTIENGESELLSCHAFT (DE) 1988-04-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230303570-A1 KINASE INHIBITORS AND USES THEREOF ERBB2, ERBB3, ERBB4 MAPT 2358/4885LMNA 3263/4885PRKDC 127/4885
US-11807641-B2 MASP-2 inhibitors and methods of use MASP2, METAP2, SPINT2 MAPT 3549/4885LMNA 3425/4885PRKDC 1344/4885
US-20230357199-A1 ARYL, HETEROARYL, AND HETEROCYCLIC PHARMACEUTICAL COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS CFD, TFPI, CFH MAPT 4491/4885LMNA 2135/4885PRKDC 2052/4885
US-20230382909-A1 BICYCLIC COMPOUNDS SLC10A1, PKD1, CYP11B2 MAPT 1168/4885LMNA 1338/4885PRKDC 3437/4885
US-20230374008-A1 BICYCLIC COMPOUNDS SLC10A1, PKD1, CYP11B2 MAPT 1168/4885LMNA 1338/4885PRKDC 3437/4885
US-11814391-B2 Macrocyclic compounds for the treatment of medical disorders CFD, TFPI, CFH MAPT 3007/4885LMNA 816/4885PRKDC 1060/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.