Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 9/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 7/20 | 0.38 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22685262 | 0.92 | WDR91 (0.40) | PDE2AHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22685264 | 0.90 | PDE2A (0.42) | PDE2AHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22685329 | 0.89 | IDO1 (0.43) | HDAC3HDAC1HDAC2HDAC6IDO1 | |
| SCHEMBL22685327 | 0.83 | PDE2A (0.39) | PDE2AIDO1CYP3A4CYP2C8 | |
| SCHEMBL22685074 | 0.79 | IDO1 (0.51) | PDE2AHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22685249 | 0.79 | WDR91 (0.41) | HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22685247 | 0.79 | ROCK2 (0.41) | PDE2AHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22685250 | 0.79 | PTPN1 (0.40) | PDE2AHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22686804 | 0.78 | PDE2A (0.47) | PDE2AHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22684761 | 0.76 | HDAC1 (0.44) | HDAC3HDAC1HDAC2HDAC6IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020228823-A1 | NOVEL AMIDE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2020-11-19 | — | — | WO | disclosed |