Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR91 | A4D1P6 | 3/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22685311 | 0.92 | WDR91 (0.55) | WDR91HSD11B1MAP4K4DYRK1ADYRK1B | |
| SCHEMBL22686788 | 0.86 | HDAC3 (0.46) | WDR91MAP4K4HDAC3HDAC1HDAC2 | |
| SCHEMBL22686783 | 0.84 | WDR91 (0.42) | WDR91MAP4K4ROCK2ROCK1HDAC3 | |
| SCHEMBL22685237 | 0.83 | BTK (0.41) | WDR91HSD11B1MAP4K4HDAC3HDAC1 | |
| SCHEMBL22685249 | 0.82 | WDR91 (0.41) | WDR91MAP4K4ROCK2ROCK1HDAC3 | |
| SCHEMBL22686791 | 0.81 | WDR91 (0.44) | WDR91HSD11B1MAP4K4HDAC3HDAC1 | |
| SCHEMBL22685198 | 0.79 | WDR91 (0.53) | WDR91MAP4K4HDAC3HDAC1HDAC2 | |
| SCHEMBL22685255 | 0.79 | HDAC3 (0.39) | MAP4K4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22685238 | 0.77 | HDAC3 (0.47) | WDR91HSD11B1HDAC3HDAC1HDAC2 | |
| SCHEMBL22685183 | 0.77 | MALT1 (0.44) | WDR91ROCK2ROCK1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020228823-A1 | NOVEL AMIDE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2020-11-19 | — | — | WO | disclosed |