Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN9 | O14815 | 3/20 | 0.53 |
| ▸ | CAPN1 | P07384 | 11/20 | 0.51 |
| ▸ | CTSK | P43235 | 2/20 | 0.51 |
| ▸ | CTSB | P07858 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSH | P09668 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.51 |
| ▸ | CTSC | P53634 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | NPY4R | P50391 | 4/20 | 0.38 |
| ▸ | NPY1R | P25929 | 3/20 | 0.38 |
| ▸ | NPY2R | P49146 | 3/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23133278 | 1.00 | CAPN9 (0.53) | CAPN9CAPN1CTSKCTSBMAPK1 | |
| SCHEMBL20422767 | 1.00 | CAPN9 (0.53) | CAPN9CAPN1CTSKCTSBMAPK1 | |
| SCHEMBL20422771 | 1.00 | CAPN9 (0.53) | CAPN9CAPN1CTSKCTSBMAPK1 | |
| SCHEMBL20422774 | 1.00 | CAPN9 (0.53) | CAPN9CAPN1CTSKCTSBMAPK1 | |
| SCHEMBL22687573 | 1.00 | CAPN9 (0.53) | CAPN9CAPN1CTSKCTSBMAPK1 | |
| E-64 SCHEMBL13283063 | 0.81 | CAPN1 (0.74) | CAPN9CAPN1CTSKCTSBMAPK1 | |
| E-64 SCHEMBL23132676 | 0.81 | CAPN1 (0.74) | CAPN9CAPN1CTSKCTSBMAPK1 | |
| E-64 SCHEMBL13523481 | 0.81 | CAPN1 (0.74) | CAPN9CAPN1CTSKCTSBMAPK1 | |
| E-64 SCHEMBL16452857 | 0.81 | CAPN1 (0.74) | CAPN9CAPN1CTSKCTSBMAPK1 | |
| E-64 SCHEMBL7087294 | 0.81 | CAPN1 (0.74) | CAPN9CAPN1CTSKCTSBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12383554-B2 | Compositions and methods to protect mammalian tissue against cold and other metabolic stresses | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2025-08-12 | — | — | US | claimed |
| CN-112105366-B | Compositions and methods for protecting mammalian tissue against cold and other metabolic stresses | 由卫生与公众服务部部长代表的美利坚合众国 | 2024-04-05 | — | — | CN | claimed |
| US-20230095075-A1 | COMPOSITIONS AND METHODS TO PROTECT MAMMALIAN TISSUE AGAINST COLD AND OTHER METABOLIC STRESSES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES | 2023-03-30 | — | — | US | claimed |
| US-20200368230-A1 | COMPOSITIONS AND METHODS TO PROTECT MAMMALIAN TISSUE AGAINST COLD AND OTHER METABOLIC STRESSES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2020-11-26 | — | — | US | claimed |
| US-12383554-B2 | Compositions and methods to protect mammalian tissue against cold and other metabolic stresses | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2025-08-12 | — | — | US | disclosed |
| CN-112105366-B | Compositions and methods for protecting mammalian tissue against cold and other metabolic stresses | 由卫生与公众服务部部长代表的美利坚合众国 | 2024-04-05 | — | — | CN | disclosed |
| US-20230095075-A1 | COMPOSITIONS AND METHODS TO PROTECT MAMMALIAN TISSUE AGAINST COLD AND OTHER METABOLIC STRESSES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES | 2023-03-30 | — | — | US | disclosed |
| US-11547708-B2 | Compositions and methods to protect mammalian tissue against cold and other metabolic stresses | THE USA, AS REPRESENTED BY THE SECRETARY, DHHS (US) | 2023-01-10 | — | — | US | disclosed |
| EP-4081233-A1 | COMPOSITION AND METHODS OF MANUFACTURE | Phoenix Eagle Company Pty Ltd (AU) | 2022-11-02 | — | — | EP | disclosed |
| WO-2022140817-A1 | ANTI-VIRAL PROTEASES AND METHODS OF USE | PHOENIX EAGLE COMPANY PTY LTD (AU) | 2022-07-07 | — | — | WO | disclosed |
| EP-4009053-A1 | METHODS FOR PREVENTING ACUTE KIDNEY INJURY | University Of Maryland, Baltimore (US) | 2022-06-08 | — | — | EP | disclosed |
| WO-2022031931-A2 | COMPOSITIONS FOR ALTERING A MICROGLIAL CELL, AND METHODS OF USE THEREFORE | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2022-02-10 | — | — | WO | disclosed |
| US-20210085639-A1 | METHODS FOR PREVENTING ACUTE KIDNEY INJURY | UNIVERSITY OF MARYLAND, BALTIMORE | 2021-03-25 | — | — | US | disclosed |
| US-20200368230-A1 | COMPOSITIONS AND METHODS TO PROTECT MAMMALIAN TISSUE AGAINST COLD AND OTHER METABOLIC STRESSES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2020-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200368230-A1 | COMPOSITIONS AND METHODS TO PROTECT MAMMALIAN TISSUE AGAINST COLD AND OTHER METABOLIC STRESSES | TXN2, HSPA9, TXNRD2 | CAPN9 343/4885CAPN1 567/4885CTSK 339/4885 |
| US-11547708-B2 | Compositions and methods to protect mammalian tissue against cold and other metabolic stresses | TXN2, HSPA9, TXNRD2 | CAPN9 343/4885CAPN1 567/4885CTSK 339/4885 |
| US-12383554-B2 | Compositions and methods to protect mammalian tissue against cold and other metabolic stresses | TXN2, HSPA9, TXNRD2 | CAPN9 343/4885CAPN1 567/4885CTSK 339/4885 |
| US-20230095075-A1 | COMPOSITIONS AND METHODS TO PROTECT MAMMALIAN TISSUE AGAINST COLD AND OTHER METABOLIC STRESSES | TXN2, HSPA9, TXNRD2 | CAPN9 343/4885CAPN1 567/4885CTSK 339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.