SCHEMBL2269062

SCHEMBL2269062

C=C[Si](NCC)(c1ccccc1)c1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 1/20 0.33
HDAC8 Q9BY41 1/20 0.32
IDH1 O75874 1/20 0.32
ALDH1A1 P00352 2/20 0.31
TSHR P16473 1/20 0.31
TP53 P04637 1/20 0.31
MAPT P10636 1/20 0.31
SIGMAR1 Q99720 1/20 0.31
KDM4E B2RXH2 1/20 0.31
GAA P10253 1/20 0.31
HPGD P15428 1/20 0.31
CCNA2 P20248 1/20 0.30
CDK2 P24941 1/20 0.30
AKT1 P31749 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30
HTT P42858 1/20 0.30
TLR8 Q9NR97 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2103464 0.79 KCNN4 (0.33) KCNN4HDAC8IDH1ALDH1A1TSHR
SCHEMBL2269681 0.78 ALDH1A1 (0.33) KCNN4HDAC8IDH1ALDH1A1TSHR
SCHEMBL157867 0.78 ALDH1A1 (0.36) IDH1ALDH1A1TSHRAKT1
SCHEMBL2100179 0.76 KCNN4 (0.31) KCNN4HDAC8
SCHEMBL2269585 0.73 KCNN4 (0.33) KCNN4ALDH1A1MAPT
SCHEMBL2102124 0.73
SCHEMBL3004847 0.73 HTT (0.30) HTT
SCHEMBL2275031 0.73 SIGMAR1 (0.34) SIGMAR1HTT
SCHEMBL2271394 0.71 SIGMAR1 (0.34) ALDH1A1TSHRMAPTSIGMAR1HTT
SCHEMBL2267447 0.71 SIGMAR1 (0.33) SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404584-B2 Method of manufacturing semiconductor device FUJITSU LIMITED (JP) 2013-03-26 US disclosed
US-20110207319-A1 METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE FUJITSU LIMITED (JP) 2011-08-25 US disclosed