SCHEMBL2269167

SCHEMBL2269167

O=C(Nc1cc(C=Cc2ccc(F)cc2F)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SNCA P37840 5/20 0.59
HDAC1 Q13547 1/20 0.51
MEN1 O00255 2/20 0.50
PKM P14618 2/20 0.50
KMT2A Q03164 2/20 0.50
MAPT P10636 1/20 0.50
GRIK1 P39086 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
HTR2A P28223 4/20 0.48
HTR2C P28335 4/20 0.48
KCNH2 Q12809 2/20 0.48
NFE2L2 Q16236 2/20 0.47
KCNK2 O95069 2/20 0.46
BCL2L1 Q07817 1/20 0.46
BAD Q92934 1/20 0.46
TRPA1 O75762 1/20 0.44
KCNK10 P57789 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2269158 1.00 SNCA (0.59) SNCAHDAC1MEN1PKMKMT2A
SCHEMBL2276918 0.89 SNCA (0.66) SNCAHDAC1MEN1PKMKMT2A
SCHEMBL2276923 0.89 SNCA (0.66) SNCAHDAC1MEN1PKMKMT2A
SCHEMBL14428149 0.88 SNCA (0.59) SNCAHDAC1MEN1KMT2AHTR2A
SCHEMBL27716652 0.85 SNCA (0.63) SNCAHDAC1MEN1PKMKMT2A
SCHEMBL2272560 0.85 KMT2A (0.55) SNCAHDAC1MEN1PKMKMT2A
SCHEMBL2272567 0.85 KMT2A (0.55) SNCAHDAC1MEN1PKMKMT2A
SCHEMBL2276651 0.84 PKM (0.62) SNCAHDAC1MEN1PKMKMT2A
SCHEMBL2276655 0.84 PKM (0.62) SNCAHDAC1MEN1PKMKMT2A
SCHEMBL27696878 0.83 SNCA (0.57) SNCAHDAC1MEN1PKMKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 SNCA 4741/4885HDAC1 71/4885MEN1 3105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.