Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14629798 | 0.67 | PKM (0.43) | — | |
| SCHEMBL5567319 | 0.67 | MAPK10 (0.35) | HIF1ATLR7MAPK10KDM4E | |
| SCHEMBL5567321 | 0.65 | GRM5 (0.46) | — | |
| SCHEMBL14457205 | 0.63 | TLR7 (0.37) | HIF1ATLR7KDM4E | |
| SCHEMBL2643079 | 0.62 | RAB9A (0.47) | HIF1ATLR7KDM4E | |
| SCHEMBL2643511 | 0.61 | — | — | |
| SCHEMBL19036256 | 0.61 | TLR7 (0.36) | HIF1ATLR7KDM4E | |
| SCHEMBL2485900 | 0.61 | HIF1A (0.45) | HIF1ATLR7KDM4E | |
| SCHEMBL31752320 | 0.60 | ALDH1A1 (0.45) | HIF1ATLR7KDM4E | |
| Bromide SCHEMBL10983160 | 0.60 | TLR7 (0.47) | HIF1ATLR7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10844053-B2 | Pyrazol-3-ones that activate pro-apoptotic BAX | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10844053-B2 | Pyrazol-3-ones that activate pro-apoptotic BAX | BAX, BAD, CASP3 | HIF1A 2095/4885TLR7 3739/4885MAPK10 1370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.