SCHEMBL2269632

SCHEMBL2269632

O=C(Nc1cc(-c2c(F)cccc2Cl)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ACLY P53396 7/20 0.59
MEN1 O00255 4/20 0.51
KMT2A Q03164 4/20 0.51
GRIK1 P39086 3/20 0.51
PKM P14618 2/20 0.51
MAPT P10636 2/20 0.51
TDP1 Q9NUW8 1/20 0.51
SUCNR1 Q9BXA5 1/20 0.51
PRSS12 P56730 1/20 0.49
SERPINE1 P05121 2/20 0.48
RAB9A P51151 2/20 0.48
NPC1 O15118 1/20 0.48
LMNA P02545 1/20 0.48
HPGD P15428 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
DHODH Q02127 1/20 0.48
FABP3 P05413 1/20 0.47
FABP4 P15090 1/20 0.47
FABP5 Q01469 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2276831 0.91 ACLY (0.59) ACLYMEN1KMT2AGRIK1PKM
SCHEMBL2272742 0.85 ACLY (0.43) ACLYMEN1KMT2AMAPTPRSS12
SCHEMBL2269869 0.84 ACLY (0.67) ACLYMEN1KMT2AGRIK1PKM
SCHEMBL27696865 0.83 ACLY (0.42) ACLYMEN1KMT2AMAPTTDP1
SCHEMBL2270919 0.83 ACLY (0.56) ACLYMEN1KMT2AGRIK1PKM
SCHEMBL2270359 0.81 MEN1 (0.57) ACLYMEN1KMT2AGRIK1PKM
SCHEMBL2275464 0.81 PRSS12 (0.65) ACLYMEN1KMT2AGRIK1PKM
SCHEMBL2273941 0.81 ACLY (0.59) ACLYMEN1KMT2AGRIK1PKM
SCHEMBL2270510 0.81 MEN1 (0.54) ACLYMEN1KMT2AGRIK1PKM
SCHEMBL2273555 0.81 ACLY (0.58) ACLYMEN1KMT2AGRIK1PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101094829-B novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO.,LTD. (JP) 2012-02-08 CN disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
CN-101094829-A Novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD (JP) 2007-12-26 CN disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 ACLY 653/4885MEN1 3105/4885KMT2A 1669/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.