Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | EEF2K | O00418 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837306 | 0.79 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL9837302 | 0.79 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL22699251 | 0.78 | SMN1; SMN2 (0.42) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL7910316 | 0.74 | SLC9A1 (0.49) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL8132478 | 0.73 | SLC9A1 (0.62) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL7910295 | 0.72 | SLC9A1 (0.65) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL8260539 | 0.68 | RAB9A (0.48) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL22699160 | 0.67 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL7910336 | 0.67 | SLC9A1 (0.48) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL927885 | 0.66 | SLC9A1 (0.60) | ALDH1A1SMN1; SMN2MAPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020236688-A1 | NATRIURETIC PEPTIDE RECEPTOR A AGONISTS USEFUL FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES, KIDNEY DISEASE AND DIABETES | MERCK SHARP & DOHME CORP. (US) | 2020-11-26 | — | — | WO | disclosed |