SCHEMBL22701147

SCHEMBL22701147

Cc1nc(-c2ccn3cc(NC=O)nc3c2)no1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.43
PLK1 P53350 1/20 0.38
CA12 O43570 2/20 0.36
CA1 P00915 2/20 0.36
CA2 P00918 2/20 0.36
CA9 Q16790 2/20 0.36
MAPT P10636 4/20 0.33
LMNA P02545 3/20 0.33
TP53 P04637 3/20 0.33
POLB P06746 2/20 0.33
HTT P42858 2/20 0.33
HPGD P15428 1/20 0.33
MAPK14 Q16539 2/20 0.33
RAB9A P51151 2/20 0.33
GSK3B P49841 1/20 0.33
TSHR P16473 1/20 0.33
NFKB1 P19838 1/20 0.33
NFKB2 Q00653 1/20 0.33
RELA Q04206 1/20 0.33
NPC1 O15118 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4072807 0.78
SCHEMBL17643621 0.72 USP30 (0.47) MAPTLMNATP53POLB
SCHEMBL21845508 0.71 LMNA (0.39) MAPTLMNATP53POLBMAPK14
SCHEMBL19287155 0.70 L3MBTL1 (0.64) L3MBTL1PLK1CA12CA1CA2
SCHEMBL6285527 0.66 PTGS1 (0.47) L3MBTL1MAPTLMNATP53POLB
SCHEMBL23451298 0.65 BRD4 (0.39)
SCHEMBL5222748 0.65 KDM4E (0.48) L3MBTL1PLK1MAPTTP53POLB
SCHEMBL3147788 0.64 CA12 (0.57) L3MBTL1PLK1CA12CA1CA2
SCHEMBL12605591 0.64 L3MBTL1 (0.53) L3MBTL1PLK1CA12CA1CA2
SCHEMBL44509 0.63 L3MBTL1 (0.60) L3MBTL1MAPTLMNATP53POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200369658-A1 NOVEL COMPOUNDS MISSION THERAPEUTICS LTD (GB) 2020-11-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200369658-A1 NOVEL COMPOUNDS UCHL1, UCHL3, UCHL5 L3MBTL1 400/4885PLK1 718/4885CA12 2591/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.