SCHEMBL2270464

SCHEMBL2270464

Cc1ccc(C(=O)c2ccccc2)cc1N

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.63
TDP1 Q9NUW8 2/20 0.63
LMNA P02545 3/20 0.57
NPC1 O15118 2/20 0.57
MITF O75030 1/20 0.57
POLB P06746 1/20 0.57
MAPK1 P28482 3/20 0.57
PBRM1 Q86U86 1/20 0.56
L3MBTL1 Q9Y468 2/20 0.55
ATM Q13315 1/20 0.55
ALDH1A1 P00352 4/20 0.52
SMN1; SMN2 Q16637 4/20 0.50
HTT P42858 2/20 0.50
CES2 O00748 1/20 0.50
CES1 P23141 1/20 0.50
SRD5A2 P31213 1/20 0.50
MAPK13 O15264 1/20 0.49
MAPK12 P53778 1/20 0.49
MAPK11 Q15759 1/20 0.49
MAPK14 Q16539 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13783388 0.90 MAPT (0.76) MAPTTDP1LMNANPC1MITF
SCHEMBL19070622 0.87 MAPT (0.66) MAPTTDP1LMNANPC1MITF
SCHEMBL4609604 0.85 POLB (0.57) MAPTTDP1LMNANPC1MITF
SCHEMBL20628703 0.85 MAPT (0.68) MAPTTDP1LMNANPC1MITF
SCHEMBL13783385 0.83 MAPT (0.66) MAPTTDP1LMNANPC1MITF
SCHEMBL166495 0.82 SMN1; SMN2 (0.71) MAPTTDP1LMNANPC1MITF
SCHEMBL144914 0.82 PBRM1 (0.62) MAPTTDP1LMNANPC1POLB
SCHEMBL30874183 0.82 PBRM1 (0.62) MAPTTDP1LMNANPC1POLB
Benzophenone SCHEMBL27781305 0.82 PBRM1 (0.62) MAPTTDP1LMNANPC1POLB
SCHEMBL10007010 0.82 SMN1; SMN2 (0.71) MAPTTDP1LMNANPC1MITF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101056632-B Compounds and compositions as protein kinase inhibitors IRM LLC (BM) 2011-12-07 CN claimed
US-8327467-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2012-12-11 US disclosed
US-8327467-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2012-12-11 US disclosed
US-8327467-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2012-12-11 US disclosed
EP-1860098-B1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO LTD (JP) 2012-11-14 EP disclosed
CN-101056632-B Compounds and compositions as protein kinase inhibitors IRM LLC (BM) 2011-12-07 CN disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
US-20090105474-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-04-23 US disclosed
EP-1860098-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-11-28 EP disclosed
EP-1860098-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-11-28 EP disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed
US-6623786-B2 Method for hydrogel surface treatment NOVARTIS AG (CH) 2003-09-23 US disclosed
US-20010024697-A1 Method for hydrogel surface treatment and article formed therefrom BARON RICHARD CARLTON (US) 2001-09-27 US disclosed
EP-1023617-A1 METHOD FOR HYDROGEL SURFACE TREATMENT AND ARTICLE FORMED THEREFROM Novartis AG (CH) 2000-08-02 EP disclosed
WO-1999015917-A1 METHOD FOR HYDROGEL SURFACE TREATMENT AND ARTICLE FORMED THEREFROM NOVARTIS AG (CH) 1999-04-01 WO disclosed
CN-1151187-A Subtilisin 309 variants having decreased absorption and increased hydrolysis PROCTER & GAMBLE (US) 1997-06-04 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MAPT 4824/4885TDP1 3823/4885LMNA 3235/4885
US-20090105474-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP11, MMP3 MAPT 4791/4885TDP1 4378/4885LMNA 3194/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.