Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | TDP2 | O95551 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21090322 | 0.72 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1ALPLGAAALPG | |
| SCHEMBL21090321 | 0.72 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1L3MBTL1ALPLGAA | |
| SCHEMBL22686671 | 0.71 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1ALPLGAAALPG | |
| SCHEMBL15642447 | 0.70 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1HSP90AA1HSP90AB1HTT | |
| SCHEMBL21052432 | 0.69 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1L3MBTL1ALPLGAA | |
| SCHEMBL16253385 | 0.69 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1GAAMAPTLMNA | |
| SCHEMBL14580998 | 0.69 | ITGA4 (0.55) | SMN1; SMN2ALDH1A1HSP90AA1HSP90AB1KDM4E | |
| SCHEMBL21090323 | 0.68 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1ALPLGAAALPG | |
| SCHEMBL15642518 | 0.67 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1HSP90AA1HSP90AB1HTT | |
| SCHEMBL8371904 | 0.67 | ALDH1A1 (1.00) | SMN1; SMN2ALDH1A1HSP90AA1HSP90AB1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230201799-A1 | Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2023-06-29 | — | — | US | disclosed |
| US-20230201799-A1 | Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2023-06-29 | — | — | US | disclosed |
| US-20200368721-A1 | Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2020-11-26 | — | — | US | disclosed |