Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503189 | 0.89 | KMT2A (0.40) | MAOBALDH1A1MAPK1KMT2AMAPT | |
| SCHEMBL30193078 | 0.89 | KMT2A (0.40) | MAOBALDH1A1MAPK1KMT2AMAPT | |
| SCHEMBL22719906 | 0.86 | FRK (0.42) | ALDH1A1MAPK1KMT2AMAPT | |
| SCHEMBL1503147 | 0.82 | ALDH1A1 (0.39) | MAOBALDH1A1MAPK1KMT2A | |
| SCHEMBL12398991 | 0.80 | KMT2A (0.48) | MAOBALDH1A1MAPK1KMT2ALMNA | |
| SCHEMBL1503248 | 0.80 | ALDH1A1 (0.39) | MAOBALDH1A1MAPK1KMT2AMAPT | |
| SCHEMBL22719912 | 0.80 | KMT2A (0.39) | MAOBALDH1A1MAPK1KMT2ALMNA | |
| SCHEMBL1503150 | 0.79 | KMT2A (0.47) | MAOBALDH1A1MAPK1KMT2AMAPT | |
| SCHEMBL22719914 | 0.79 | KMT2A (0.43) | MAOBALDH1A1MAPK1KMT2AMAPT | |
| SCHEMBL22719947 | 0.77 | LMNA (0.46) | ALDH1A1MAPK1KMT2ALMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |