Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 14/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22719930 | 0.91 | PPARG (0.39) | PPARGMAOB | |
| SCHEMBL22738235 | 0.90 | ALDH1A1 (0.37) | MAOBALDH1A1MAPK1KMT2A | |
| SCHEMBL22738287 | 0.90 | MTNR1A (0.41) | PPARGALDH1A1MAPK1KMT2A | |
| SCHEMBL22738232 | 0.90 | ALDH1A1 (0.35) | MAOBALDH1A1MAPK1KMT2A | |
| SCHEMBL22719921 | 0.88 | NPY5R (0.39) | PPARGMAOBGRIN2B | |
| SCHEMBL22719944 | 0.87 | HDAC1 (0.36) | PPARGMAOBALDH1A1MAPK1KMT2A | |
| SCHEMBL22738280 | 0.85 | ALDH1A1 (0.51) | PPARGMAOBALDH1A1MAPK1KMT2A | |
| SCHEMBL22738309 | 0.82 | EGLN1 (0.44) | PPARG | |
| SCHEMBL22738238 | 0.81 | ALDH1A1 (0.37) | MAOBALDH1A1MAPK1KMT2A | |
| SCHEMBL22719901 | 0.81 | EGLN1 (0.35) | PPARGMAOBALDH1A1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |