Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KRAS | P01116 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22738238 | 0.91 | ALDH1A1 (0.37) | EGLN1ALDH1A1MAPK1KMT2AHCRTR1 | |
| SCHEMBL22738309 | 0.91 | EGLN1 (0.44) | EGLN1HCRTR1HCRTR2HDAC8HDAC6 | |
| SCHEMBL22719930 | 0.91 | PPARG (0.39) | EGLN1MAOBPPARG | |
| SCHEMBL22738232 | 0.90 | ALDH1A1 (0.35) | ALDH1A1MAPK1KMT2AKRASHCRTR1 | |
| SCHEMBL22719911 | 0.85 | HTR2A (0.37) | EGLN1ALDH1A1MAPK1KMT2AHCRTR1 | |
| SCHEMBL22738287 | 0.82 | MTNR1A (0.41) | EGLN1ALDH1A1MAPK1KMT2AHCRTR1 | |
| SCHEMBL22738235 | 0.82 | ALDH1A1 (0.37) | ALDH1A1MAPK1KMT2AHCRTR1HCRTR2 | |
| SCHEMBL22719921 | 0.81 | NPY5R (0.39) | EGLN1MAOBPPARG | |
| SCHEMBL22719923 | 0.81 | MTNR1A (0.40) | ALDH1A1HDAC8HDAC6HDAC11HDAC3 | |
| SCHEMBL22719960 | 0.81 | PPARG (0.38) | ALDH1A1MAPK1KMT2AMAOBPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |