Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPD1 | P10809 | 1/20 | 0.55 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.55 |
| ▸ | GPR27 | Q9NS67 | 4/20 | 0.54 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.54 |
| ▸ | F12 | P00748 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PRKCI | P41743 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10289025 | 0.87 | POLB (0.61) | HSPD1HSPE1GPR27AVPR2F12 | |
| SCHEMBL15920888 | 0.86 | ALDH1A1 (0.59) | GPR27AVPR2NPC1RAB9AALDH1A1 | |
| SCHEMBL2545034 | 0.84 | MAPT (0.50) | SORT1ALDH1A1KMT2AMEN1TP53 | |
| SCHEMBL15920940 | 0.84 | KMT2A (0.69) | NPC1RAB9ASORT1ALDH1A1P2RX1 | |
| SCHEMBL3341952 | 0.83 | ALDH1A1 (0.53) | ALDH1A1P2RX1HTTKMT2AMEN1 | |
| SCHEMBL23825504 | 0.82 | SORT1 (0.74) | HSPD1HSPE1GPR27AVPR2F12 | |
| SCHEMBL29980628 | 0.82 | SORT1 (0.74) | HSPD1HSPE1GPR27AVPR2F12 | |
| SCHEMBL19329033 | 0.81 | MEN1 (0.65) | HSPD1HSPE1GPR27AVPR2F12 | |
| SCHEMBL19350786 | 0.81 | GPR27 (0.74) | HSPD1HSPE1GPR27AVPR2F12 | |
| SCHEMBL10430505 | 0.81 | FADS1 (0.56) | GPR27AVPR2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117510415-A | Synthesis method of quinazolinone compound | 中国人民解放军军事科学院防化研究院 | 2024-02-06 | — | — | CN | disclosed |
| WO-2020239050-A1 | 2-(2-CHLORO-4-METHYLPHENYL)QUINAZOLINE-4(3H)-KETONE COMPOUND AND MEDICAL USE THEREOF | 中国人民解放军军事科学院军事医学研究院 | 2020-12-03 | — | — | WO | disclosed |
| CN-110041272-B | 2- (2-chlorphenyl) quinazoline-4 (3H) -ketone derivative and preparation method and application thereof | 中国人民解放军军事科学院军事医学研究院 | 2020-10-30 | — | — | CN | disclosed |
| CN-110041273-B | 2- (2-chloro-4-methylphenyl) quinazoline-4 (3H) -ketone compound and medical application thereof | 中国人民解放军军事科学院军事医学研究院 | 2020-10-20 | — | — | CN | disclosed |
| CN-110041273-A | 2- (the chloro- 4- aminomethyl phenyl of 2-) quinazoline -4 (3H) -one class compound and its medical usage | 中国人民解放军军事科学院军事医学研究院 | 2019-07-23 | — | — | CN | disclosed |
| CN-110041272-A | 2- (2- chlorphenyl) quinazoline -4 (3H) -one analog derivative and its preparation method and application | 中国人民解放军军事科学院军事医学研究院 | 2019-07-23 | — | — | CN | disclosed |