SCHEMBL2272069

SCHEMBL2272069

CCC([SiH3])c1ccccc1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NISCH Q9Y2I1 1/20 0.44
ADRB2 P07550 2/20 0.42
ADRB1 P08588 2/20 0.42
AOC3 Q16853 1/20 0.42
HIF1A Q16665 3/20 0.41
CYP2D6 P10635 2/20 0.41
NFKB1 P19838 2/20 0.41
BLM P54132 2/20 0.40
CASP1 P29466 1/20 0.39
TSHR P16473 4/20 0.38
LMNA P02545 2/20 0.38
MC4R P32245 1/20 0.37
CYP3A4 P08684 2/20 0.37
IDO1 P14902 2/20 0.37
TDO2 P48775 2/20 0.37
IDO2 Q6ZQW0 2/20 0.37
CYP2C19 P33261 2/20 0.37
CYP2C9 P11712 1/20 0.37
KDM4E B2RXH2 1/20 0.37
NR1I2 O75469 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9233119 0.84 TSHR (0.44) TSHRLMNAIDO1SLC6A2SLC6A4
SCHEMBL2102355 0.83 PNMT (0.52) NISCHADRB2ADRB1AOC3CYP2D6
SCHEMBL2102663 0.77 NISCH (0.38) NISCHAOC3CYP2D6NFKB1LMNA
SCHEMBL2102181 0.77 CXCL8 (0.35) NISCHADRB2ADRB1HIF1ACYP2D6
SCHEMBL2632968 0.77 NISCH (0.47) NISCHADRB2ADRB1AOC3HIF1A
SCHEMBL2102669 0.76 CYP1A2 (0.33) NISCHAOC3CYP2D6NFKB1LMNA
SCHEMBL2103218 0.76 CXCL8 (0.34) NISCHADRB2ADRB1HIF1ACYP2D6
SCHEMBL17790152 0.76 TSHR (0.59) NISCHADRB2ADRB1AOC3HIF1A
SCHEMBL6678860 0.76 NISCH (0.46) NISCHADRB2ADRB1AOC3HIF1A
SCHEMBL3789761 0.76 TSHR (0.59) NISCHADRB2ADRB1AOC3HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404584-B2 Method of manufacturing semiconductor device FUJITSU LIMITED (JP) 2013-03-26 US disclosed
US-20110207319-A1 METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE FUJITSU LIMITED (JP) 2011-08-25 US disclosed