SCHEMBL2272184

SCHEMBL2272184

CCC[Si](NC)(c1ccccc1)c1ccccc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.32
KDM4E B2RXH2 3/20 0.32
MAPT P10636 2/20 0.32
CYP3A4 P08684 1/20 0.32
TP53 P04637 1/20 0.32
TSHR P16473 1/20 0.32
APP P05067 1/20 0.32
ALDH1A1 P00352 2/20 0.31
HPGD P15428 2/20 0.31
GAA P10253 2/20 0.31
ATM Q13315 1/20 0.31
TAAR1 Q96RJ0 1/20 0.31
USP2 O75604 1/20 0.31
POLB P06746 1/20 0.31
RECQL P46063 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
HSD17B10 Q99714 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
NAAA Q02083 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2272798 0.83 GAA (0.35) KMT2AKDM4EMAPTTP53APP
SCHEMBL2101644 0.78 NR1H2 (0.32) KMT2AKDM4EMAPTCYP3A4TP53
SCHEMBL20499846 0.77 ESR1 (0.33) KMT2AKDM4EMAPTCYP3A4TP53
Dimethylamine SCHEMBL8199596 0.76 ESR1 (0.41) KMT2AKDM4EMAPTCYP3A4TP53
SCHEMBL2102178 0.75 MAPT (0.31) KMT2AKDM4EMAPTCYP3A4TP53
SCHEMBL2272188 0.75 KMT2A (0.31) KMT2AKDM4EMAPTCYP3A4TP53
SCHEMBL2275568 0.74 TAAR1 (0.34) KMT2AMAPTALDH1A1TAAR1POLB
SCHEMBL704482 0.73 TP53 (0.35) KMT2AKDM4EMAPTTP53TSHR
SCHEMBL3889886 0.72 NR1H2 (0.50) KMT2AKDM4EMAPTTP53TSHR
SCHEMBL10730048 0.72 ESR1 (0.45) KMT2AKDM4EMAPTTP53TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404584-B2 Method of manufacturing semiconductor device FUJITSU LIMITED (JP) 2013-03-26 US disclosed
US-20110207319-A1 METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE FUJITSU LIMITED (JP) 2011-08-25 US disclosed