SCHEMBL2272197

SCHEMBL2272197

CN[SiH2]CCC(c1ccccc1)c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 8/20 0.55
HTR2A P28223 8/20 0.55
CYP3A4 P08684 3/20 0.46
KCNH2 Q12809 3/20 0.46
ADRA1A P35348 3/20 0.46
CYP2D6 P10635 3/20 0.46
HTR1A P08908 2/20 0.46
ADORA3 P0DMS8 2/20 0.46
SLC6A2 P23975 2/20 0.46
SLC6A4 P31645 2/20 0.46
OPRM1 P35372 2/20 0.46
DRD3 P35462 2/20 0.46
SLC6A3 Q01959 2/20 0.46
CHRM2 P08172 2/20 0.46
CYP2C19 P33261 2/20 0.46
ADRA2A P08913 1/20 0.46
CHRM1 P11229 1/20 0.46
SMPD1 P17405 1/20 0.46
DRD1 P21728 1/20 0.46
TBXA2R P21731 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2272809 0.80 HRH1 (0.47) HRH1HTR2ACYP3A4KCNH2ADRA1A
SCHEMBL707328 0.76 HRH1 (0.50) HRH1HTR2ACYP3A4KCNH2ADRA1A
SCHEMBL107889 0.72 HRH1 (0.56) HRH1HTR2ACYP3A4KCNH2ADRA1A
SCHEMBL3638413 0.71 HTR2A (1.00) HRH1HTR2ACYP3A4KCNH2ADRA1A
SCHEMBL9242182 0.71 HRH1 (0.50) HRH1HTR2ACYP3A4KCNH2ADRA1A
SCHEMBL705991 0.71 HRH1 (0.50) HRH1HTR2ACYP3A4KCNH2ADRA1A
SCHEMBL704483 0.71 HRH1 (0.50) HRH1HTR2ACYP3A4KCNH2ADRA1A
SCHEMBL3290730 0.71 HRH1 (0.68) HRH1HTR2ACYP3A4KCNH2ADRA1A
SCHEMBL705040 0.71 HRH1 (0.45) HRH1HTR2ACYP3A4KCNH2ADRA1A
SCHEMBL2272899 0.71 HRH1 (0.55) HRH1HTR2ACYP3A4KCNH2ADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404584-B2 Method of manufacturing semiconductor device FUJITSU LIMITED (JP) 2013-03-26 US disclosed
US-20110207319-A1 METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE FUJITSU LIMITED (JP) 2011-08-25 US disclosed