SCHEMBL2272899

SCHEMBL2272899

CN(C)[SiH2]CCC(c1ccccc1)c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 7/20 0.55
HTR2A P28223 6/20 0.55
TDP1 Q9NUW8 1/20 0.47
SIGMAR1 Q99720 2/20 0.44
MTNR1A P48039 1/20 0.43
MTNR1B P49286 1/20 0.43
CYP3A4 P08684 2/20 0.41
CHRM2 P08172 2/20 0.41
SLC6A2 P23975 2/20 0.41
SLC6A4 P31645 2/20 0.41
HTR1A P08908 1/20 0.41
ADRA2A P08913 1/20 0.41
ADORA3 P0DMS8 1/20 0.41
CHRM1 P11229 1/20 0.41
SMPD1 P17405 1/20 0.41
DRD1 P21728 1/20 0.41
TBXA2R P21731 1/20 0.41
ADRA1A P35348 1/20 0.41
OPRM1 P35372 1/20 0.41
DRD3 P35462 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2274008 0.80 SIGMAR1 (0.50) HRH1HTR2ATDP1SIGMAR1MTNR1A
SCHEMBL107889 0.72 HRH1 (0.56) HRH1HTR2ATDP1SIGMAR1MTNR1A
SCHEMBL1802493 0.71 HRH1 (1.00) HRH1HTR2ATDP1SIGMAR1CYP3A4
SCHEMBL704483 0.71 HRH1 (0.50) HRH1HTR2ATDP1SIGMAR1MTNR1A
SCHEMBL707328 0.71 HRH1 (0.50) HRH1HTR2ASIGMAR1MTNR1AMTNR1B
SCHEMBL705991 0.71 HRH1 (0.50) HRH1HTR2ATDP1SIGMAR1MTNR1A
SCHEMBL9242182 0.71 HRH1 (0.50) HRH1HTR2ASIGMAR1MTNR1AMTNR1B
SCHEMBL3290730 0.71 HRH1 (0.68) HRH1HTR2ATDP1SIGMAR1MTNR1A
SCHEMBL705040 0.71 HRH1 (0.45) HRH1HTR2ATDP1SIGMAR1MTNR1A
SCHEMBL2272197 0.71 HRH1 (0.55) HRH1HTR2ASIGMAR1MTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404584-B2 Method of manufacturing semiconductor device FUJITSU LIMITED (JP) 2013-03-26 US disclosed
US-20110207319-A1 METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE FUJITSU LIMITED (JP) 2011-08-25 US disclosed