Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 14/20 | 0.58 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.52 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.49 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.49 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18862330 | 0.95 | REN (0.55) | RENSLC15A2ERAP2ERAP1LNPEP | |
| SCHEMBL27624890 | 0.89 | SLC15A2 (0.61) | RENSLC15A2ERAP2ERAP1LNPEP | |
| SCHEMBL18857604 | 0.89 | SLC6A5 (0.50) | RENSLC15A2ERAP2ERAP1LNPEP | |
| SCHEMBL19051548 | 0.89 | REN (0.57) | RENSLC15A2ERAP2ERAP1LNPEP | |
| SCHEMBL18862465 | 0.89 | SLC15A2 (0.53) | RENSLC15A2ERAP2ERAP1LNPEP | |
| SCHEMBL18862360 | 0.87 | REN (0.52) | RENSLC15A2ERAP2ERAP1LNPEP | |
| SCHEMBL18862464 | 0.86 | GHSR (0.62) | REN | |
| SCHEMBL18862042 | 0.86 | REN (0.56) | RENSLC15A2ERAP2ERAP1LNPEP | |
| SCHEMBL18862361 | 0.84 | SLC15A2 (0.51) | RENSLC15A2HRH1SLC6A5 | |
| SCHEMBL22722179 | 0.83 | REN (0.65) | RENERAP2ERAP1LNPEPHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10851367-B2 | Tissue-specific genome engineering using CRISPR-Cas9 | PFIZER INC. (US) | 2020-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10851367-B2 | Tissue-specific genome engineering using CRISPR-Cas9 | ASGR1, LDLR, HAVCR2 | REN 2795/4885SLC15A2 1937/4885ERAP2 411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.