Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.42 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | QPCT | Q16769 | 1/20 | 0.40 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18862360 | 0.82 | REN (0.52) | HRH3HRH4REN | |
| SCHEMBL18857595 | 0.81 | REN (0.47) | HRH3HRH4REN | |
| SCHEMBL24922284 | 0.81 | SLC6A5 (0.44) | HRH3HRH4REN | |
| SCHEMBL15185921 | 0.79 | CYP3A4 (0.49) | HRH3HRH4QPCTQPCTL | |
| SCHEMBL18862329 | 0.78 | SLC15A2 (0.51) | REN | |
| SCHEMBL18862463 | 0.76 | CYP3A4 (0.43) | HRH3HRH4QPCTQPCTL | |
| SCHEMBL13467352 | 0.74 | CYP3A4 (0.49) | HRH3HRH4 | |
| SCHEMBL18857605 | 0.74 | QPCT (0.49) | HRH3HRH4QPCTQPCTL | |
| SCHEMBL18857393 | 0.74 | QPCT (0.49) | HRH3HRH4QPCTQPCTL | |
| SCHEMBL18862330 | 0.74 | REN (0.55) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10851367-B2 | Tissue-specific genome engineering using CRISPR-Cas9 | PFIZER INC. (US) | 2020-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10851367-B2 | Tissue-specific genome engineering using CRISPR-Cas9 | ASGR1, LDLR, HAVCR2 | HRH3 2269/4885HRH4 3479/4885REN 2795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.