⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18118976 | 0.69 | — | — | |
| SCHEMBL13501648 | 0.60 | — | — | |
| SCHEMBL24952554 | 0.59 | POLB (0.35) | — | |
| SCHEMBL16640167 | 0.59 | BMPR1B (0.34) | — | |
| SCHEMBL12128675 | 0.59 | ADORA2B (0.31) | — | |
| SCHEMBL9521247 | 0.58 | ADORA2B (0.34) | — | |
| SCHEMBL22246178 | 0.58 | BMPR1B (0.37) | — | |
| SCHEMBL9972888 | 0.58 | ALDH1A1 (0.40) | — | |
| SCHEMBL8737200 | 0.57 | ALDH1A1 (0.32) | — | |
| SCHEMBL22252035 | 0.57 | BMPR1B (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234953-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-07-27 | — | — | US | disclosed |
| US-20230219945-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-07-13 | — | — | US | disclosed |
| US-11358948-B2 | CRBN ligands and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2022-06-14 | — | — | US | disclosed |
| US-20200377469-A1 | CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2020-12-03 | — | — | US | disclosed |