SCHEMBL2273292

SCHEMBL2273292

O=C(CCc1ccccc1)Nc1cc(Oc2ccccc2)ccc1C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.57
KDM6B O15054 1/20 0.56
KDM4D Q6B0I6 1/20 0.56
KDM4C Q9H3R0 1/20 0.56
EGLN3 Q9H6Z9 1/20 0.56
HCAR2 Q8TDS4 12/20 0.55
KDM4E B2RXH2 2/20 0.52
FFAR1 O14842 2/20 0.51
ALDH1A1 P00352 1/20 0.51
TSHR P16473 1/20 0.51
HSD17B10 Q99714 1/20 0.51
RAB9A P51151 2/20 0.50
NPC1 O15118 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2276841 0.93 POLB (0.59) HDAC1KDM6BKDM4DKDM4CEGLN3
SCHEMBL22022903 0.88 MEN1 (0.60) HCAR2KDM4EALDH1A1SMN1; SMN2
SCHEMBL2271181 0.87 GAA (0.60) KDM6BKDM4DKDM4CKDM4EALDH1A1
SCHEMBL22022871 0.86 ALOX15 (0.57) HCAR2KDM4EALDH1A1SMN1; SMN2
SCHEMBL2275804 0.82 HCAR2 (0.63) HDAC1KDM6BKDM4DKDM4CEGLN3
SCHEMBL2270139 0.82 HCAR2 (0.62) HCAR2KDM4EALDH1A1TSHRHSD17B10
SCHEMBL2275482 0.80 HCAR2 (0.71) HDAC1KDM6BKDM4DKDM4CEGLN3
SCHEMBL1307810 0.80 ALOX15 (0.73) KDM6BKDM4DKDM4CEGLN3HCAR2
SCHEMBL10497116 0.79 HCAR2 (0.78) KDM6BKDM4DKDM4CEGLN3HCAR2
SCHEMBL4219661 0.79 KDM4C (0.64) KDM6BKDM4DKDM4CKDM4EFFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101094829-B novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO.,LTD. (JP) 2012-02-08 CN disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 HDAC1 71/4885KDM6B 729/4885KDM4D 884/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.