SCHEMBL2275804

SCHEMBL2275804

O=C(CCc1ccccc1)Nc1cc(CCc2ccccc2)ccc1C(=O)O

nearest known ligand 0.63

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 16/20 0.63
KDM6B O15054 1/20 0.63
KDM4D Q6B0I6 1/20 0.63
KDM4C Q9H3R0 1/20 0.63
EGLN3 Q9H6Z9 1/20 0.63
NPC1 O15118 1/20 0.56
RAB9A P51151 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
MAPT P10636 1/20 0.55
HTT P42858 1/20 0.55
HDAC1 Q13547 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2277948 0.92 KDM6B (0.64) HCAR2KDM6BKDM4DKDM4CEGLN3
SCHEMBL5146858 0.88 KDM4C (0.58) HCAR2KDM6BKDM4DKDM4CEGLN3
SCHEMBL2275482 0.86 HCAR2 (0.71) HCAR2KDM6BKDM4DKDM4CEGLN3
SCHEMBL1307810 0.86 ALOX15 (0.73) HCAR2KDM6BKDM4DKDM4CEGLN3
SCHEMBL10497116 0.84 HCAR2 (0.78) HCAR2KDM6BKDM4DKDM4CEGLN3
SCHEMBL27696824 0.82 KDM6B (0.56) HCAR2KDM6BKDM4DKDM4CEGLN3
SCHEMBL2273292 0.82 HDAC1 (0.57) HCAR2KDM6BKDM4DKDM4CEGLN3
SCHEMBL2271116 0.82 HCAR2 (0.56) HCAR2NPC1RAB9ASMN1; SMN2
SCHEMBL6104967 0.82 HCAR2 (0.71) HCAR2KDM6BKDM4DKDM4CEGLN3
SCHEMBL2275929 0.82 KMT2A (0.62) KDM4DKDM4CMAPTHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 HCAR2 154/4885KDM6B 729/4885KDM4D 884/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.