SCHEMBL2273506

SCHEMBL2273506

COc1cccc(C=Cc2ccc(C(=O)O)c(NC(=O)c3ccc(C(F)(F)F)cc3)c2)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNK2 O95069 2/20 0.60
KCNK10 P57789 1/20 0.60
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C19 P33261 1/20 0.52
MEN1 O00255 1/20 0.51
PKM P14618 1/20 0.51
KMT2A Q03164 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
AKR1C3 P42330 1/20 0.50
AKR1C2 P52895 1/20 0.50
NR1H4 Q96RI1 3/20 0.49
PPARG P37231 2/20 0.49
PPARD Q03181 2/20 0.49
GPBAR1 Q8TDU6 1/20 0.49
SNCA P37840 1/20 0.49
RXFP1 Q9HBX9 2/20 0.48
ABCG2 Q9UNQ0 2/20 0.48
MAPT P10636 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2273499 1.00 KCNK2 (0.60) KCNK2KCNK10CYP1A2CYP3A4CYP2D6
SCHEMBL2275582 0.90 NFE2L2 (0.56) KCNK2KCNK10MEN1PKMKMT2A
SCHEMBL2275577 0.90 NFE2L2 (0.56) KCNK2KCNK10MEN1PKMKMT2A
SCHEMBL2271828 0.89 SNCA (0.61) KCNK2KCNK10MEN1PKMKMT2A
SCHEMBL2271821 0.89 SNCA (0.61) KCNK2KCNK10MEN1PKMKMT2A
SCHEMBL27716751 0.87 TRPA1 (0.58) KCNK2KCNK10MEN1PKMKMT2A
SCHEMBL28767702 0.84 KCNK2 (0.53) KCNK2KCNK10MEN1KMT2ANR1H4
SCHEMBL2275274 0.84 SNCA (0.59) KCNK2KCNK10MEN1PKMKMT2A
SCHEMBL2275270 0.84 SNCA (0.59) KCNK2KCNK10MEN1PKMKMT2A
SCHEMBL5145298 0.84 TRPA1 (0.59) KCNK2KCNK10MEN1PKMKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 KCNK2 3527/4885KCNK10 2811/4885CYP1A2 883/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.