SCHEMBL227423

SCHEMBL227423

CC(C)(C)c1cc(-c2c3nc(c(-c4cc(C(C)(C)C)cc(C(C)(C)C)c4)c4ccc(cc5nc(cc6ccc2[nH]6)C=C5)[nH]4)C=C3)cc(C(C)(C)C)c1

nearest known ligand 0.54

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ STAT3 P40763 1/20 0.54
▸ STAT1 P42224 1/20 0.54
▸ TERT O14746 5/20 0.40
▸ TOP1 P11387 4/20 0.36
▸ CYCS P99999 3/20 0.35
▸ ENPP2 Q13822 1/20 0.35
▸ ABCG2 Q9UNQ0 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4260277 0.96 STAT3 (0.56) STAT3STAT1TERTTOP1CYCS
SCHEMBL12987775 0.96 STAT3 (0.59) STAT3STAT1TERTTOP1CYCS
SCHEMBL4261963 0.95 STAT3 (0.55) STAT3STAT1TERTTOP1CYCS
SCHEMBL31127544 0.95 STAT3 (0.58) STAT3STAT1TERTTOP1CYCS
SCHEMBL31127548 0.95 STAT3 (0.58) STAT3STAT1TERTTOP1CYCS
SCHEMBL30527240 0.91 STAT3 (0.67) STAT3STAT1TERTTOP1CYCS
SCHEMBL30527241 0.90 STAT3 (0.66) STAT3STAT1TERTTOP1CYCS
SCHEMBL28466363 0.89 STAT3 (0.52) STAT3STAT1TERTTOP1CYCS
SCHEMBL6505248 0.88 STAT3 (0.48) STAT3STAT1TERTTOP1CYCS
SCHEMBL2064907 0.86 TERT (0.51) TERTTOP1CYCSENPP2ABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10256421-B2 Fusing porphyrins with polycyclic aromatic hydrocarbons and heterocycles for optoelectronic applications UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2019-04-09 — — US disclosed
US-20170092883-A1 FUSING PORPHYRINS WITH POLYCYCLIC AROMATIC HYDROCARBONS AND HETEROCYCLES FOR OPTOELECTRONIC APPLICATIONS UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2017-03-30 — — US disclosed
US-20150280149-A1 FUSING PORPHYRINS WITH POLYCYCLIC AROMATIC HYDROCARBONS AND HETEROCYCLES FOR OPTOELECTRONIC APPLICATIONS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2015-10-01 — — US disclosed
US-9113535-B2 Fusing porphyrins with polycyclic aromatic hydrocarbons and heterocycles for optoelectronic applications THE UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2015-08-18 — — US disclosed
US-20120001155-A1 FUSING PORPHYRINS WITH POLYCYCLIC AROMATIC HYDROCARBONS AND HETEROCYCLES FOR OPTOELECTRONIC APPLICATIONS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2012-01-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10256421-B2 Fusing porphyrins with polycyclic aromatic hydrocarbons and heterocycles for optoelectronic applications PPOX, HMBS, TYR STAT3 3947/4885STAT1 3941/4885TERT 415/4885
US-20150280149-A1 FUSING PORPHYRINS WITH POLYCYCLIC AROMATIC HYDROCARBONS AND HETEROCYCLES FOR OPTOELECTRONIC APPLICATIONS PPOX, HMBS, TYR STAT3 3965/4885STAT1 3858/4885TERT 590/4885
US-20120001155-A1 FUSING PORPHYRINS WITH POLYCYCLIC AROMATIC HYDROCARBONS AND HETEROCYCLES FOR OPTOELECTRONIC APPLICATIONS PPOX, HMBS, NONO STAT3 3929/4885STAT1 3896/4885TERT 624/4885
US-20170092883-A1 FUSING PORPHYRINS WITH POLYCYCLIC AROMATIC HYDROCARBONS AND HETEROCYCLES FOR OPTOELECTRONIC APPLICATIONS PPOX, HMBS, TYR STAT3 3965/4885STAT1 3858/4885TERT 590/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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