SCHEMBL2274700

SCHEMBL2274700

O=C(Nc1cc(CCc2ccccc2)ccc1C(=O)O)c1ccc(Cl)cc1

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.55
KMT2A Q03164 3/20 0.55
PKM P14618 2/20 0.55
NPSR1 Q6W5P4 1/20 0.55
SERPINE1 P05121 2/20 0.54
ACLY P53396 1/20 0.53
PLK1 P53350 6/20 0.53
PLK3 Q9H4B4 4/20 0.53
KCNK2 O95069 1/20 0.53
KCNK10 P57789 1/20 0.53
GRIK1 P39086 2/20 0.52
PRSS12 P56730 3/20 0.52
CA2 P00918 1/20 0.52
CA9 Q16790 1/20 0.52
MAPT P10636 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
LTC4S Q16873 1/20 0.51
SUCNR1 Q9BXA5 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2275929 0.91 KMT2A (0.62) MEN1KMT2APKMACLYPLK1
SCHEMBL2271168 0.90 ACLY (0.67) MEN1KMT2APKMACLYPLK1
SCHEMBL2274007 0.89 GRIK1 (0.57) MEN1KMT2APKMNPSR1SERPINE1
SCHEMBL2271421 0.88 DHODH (0.63) MEN1KMT2APKMSERPINE1ACLY
SCHEMBL2270925 0.88 PLK1 (0.57) MEN1KMT2APKMPLK1PLK3
SCHEMBL2270227 0.88 SLC16A3 (0.58) MEN1KMT2AACLYPLK1PLK3
SCHEMBL2273138 0.88 GRIK1 (0.59) MEN1KMT2APKMSERPINE1ACLY
SCHEMBL2271182 0.87 PLK1 (0.53) MEN1KMT2APKMPLK1PLK3
SCHEMBL2271933 0.87 MEN1 (0.54) MEN1KMT2APKMPLK1PLK3
SCHEMBL2267959 0.87 PLK1 (0.65) MEN1KMT2APKMPLK1PLK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MEN1 3105/4885KMT2A 1669/4885PKM 2367/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.