SCHEMBL2271933

SCHEMBL2271933

O=C(Nc1cc(CCc2ccccc2)ccc1C(=O)O)c1ccc(F)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
NPC1 O15118 2/20 0.53
RAB9A P51151 2/20 0.53
PLK1 P53350 6/20 0.53
PLK3 Q9H4B4 4/20 0.53
MAPT P10636 1/20 0.51
PKM P14618 1/20 0.51
GRIK1 P39086 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
LTC4S Q16873 1/20 0.51
HCAR2 Q8TDS4 1/20 0.51
HDAC1 Q13547 2/20 0.50
MCL1 Q07820 1/20 0.50
BCL2A1 Q16548 1/20 0.50
KDM4E B2RXH2 1/20 0.50
ALDH1A1 P00352 1/20 0.50
HDAC3 O15379 1/20 0.50
HDAC2 Q92769 1/20 0.50
NCOR2 Q9Y618 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2271080 0.96 MEN1 (0.56) MEN1KMT2ANPC1RAB9APLK1
SCHEMBL2275929 0.91 KMT2A (0.62) MEN1KMT2APLK1PLK3MAPT
SCHEMBL2270587 0.90 LTC4S (0.48) MEN1KMT2ANPC1PLK1PLK3
SCHEMBL2271421 0.88 DHODH (0.63) MEN1KMT2ANPC1RAB9APLK1
SCHEMBL2270925 0.88 PLK1 (0.57) MEN1KMT2APLK1PLK3MAPT
SCHEMBL2269100 0.88 PLK1 (0.56) KMT2ANPC1RAB9APLK1PLK3
SCHEMBL2276254 0.88 CA12 (0.48) MEN1KMT2APLK1PLK3MAPT
SCHEMBL2275745 0.88 NPC1 (0.56) MEN1KMT2ANPC1RAB9AMAPT
SCHEMBL2270145 0.87 KMT2A (0.55) MEN1KMT2APLK1PLK3MAPT
SCHEMBL2274700 0.87 MEN1 (0.55) MEN1KMT2APLK1PLK3MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MEN1 3105/4885KMT2A 1669/4885NPC1 4836/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.