SCHEMBL2274708

SCHEMBL2274708

C=C([SiH3])c1ccccc1NCC

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.42
FABP4 P15090 1/20 0.39
JAK2 O60674 2/20 0.38
JAK1 P23458 2/20 0.38
KDM4E B2RXH2 3/20 0.38
GLA P06280 1/20 0.38
MEN1 O00255 4/20 0.36
POLB P06746 4/20 0.36
KMT2A Q03164 4/20 0.36
G6PD P11413 1/20 0.36
ALDH1A1 P00352 4/20 0.36
HPGD P15428 3/20 0.36
HSD17B10 Q99714 2/20 0.36
GAA P10253 2/20 0.36
RECQL P46063 2/20 0.35
CYP3A4 P08684 1/20 0.35
TSHR P16473 1/20 0.35
RAB9A P51151 2/20 0.35
AGTR1 P30556 1/20 0.35
HTT P42858 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2101112 0.86 KDM4E (0.34) IDO1FABP4JAK2JAK1KDM4E
SCHEMBL2103468 0.84 CYP3A4 (0.36) IDO1FABP4JAK2JAK1MEN1
SCHEMBL2557198 0.82 IDO1 (0.43) IDO1FABP4JAK2JAK1KDM4E
SCHEMBL2103687 0.81 CHEK1 (0.34) IDO1KDM4EGLAALDH1A1HPGD
Water SCHEMBL8638678 0.81 IDO1 (0.42) IDO1FABP4JAK2JAK1KDM4E
Water SCHEMBL1144744 0.81 IDO1 (0.42) IDO1FABP4JAK2JAK1KDM4E
SCHEMBL2492869 0.79 IDO1 (0.47) IDO1FABP4JAK2JAK1KDM4E
SCHEMBL21337799 0.78 IDO1 (0.40) IDO1FABP4JAK2JAK1KDM4E
SCHEMBL2270403 0.78 POLB (0.52) IDO1FABP4KDM4EMEN1POLB
SCHEMBL3900691 0.77 FABP4 (0.46) IDO1FABP4JAK2JAK1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404584-B2 Method of manufacturing semiconductor device FUJITSU LIMITED (JP) 2013-03-26 US disclosed
US-20110207319-A1 METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE FUJITSU LIMITED (JP) 2011-08-25 US disclosed