Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 7/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | MAT2A | P31153 | 1/20 | 0.31 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22748355 | 0.89 | EDNRA (0.40) | KDM4EEDNRAMALT1FOLH1LMNA | |
| SCHEMBL22760063 | 0.88 | EDNRA (0.39) | KDM4EEDNRAMALT1FOLH1LMNA | |
| SCHEMBL22747830 | 0.88 | EDNRA (0.39) | KDM4EEDNRAMALT1FOLH1LMNA | |
| SCHEMBL22747879 | 0.86 | HPGD (0.42) | KDM4EEDNRAMAT2AMAPK8LMNA | |
| SCHEMBL22760076 | 0.86 | EDNRA (0.38) | EDNRAMALT1FOLH1LMNAALDH1A1 | |
| SCHEMBL22760496 | 0.86 | REN (0.40) | KDM4EEDNRALMNAALDH1A1 | |
| SCHEMBL22760100 | 0.80 | SMN1; SMN2 (0.40) | KDM4EEDNRAALDH1A1 | |
| SCHEMBL22760177 | 0.79 | AKR1C3 (0.44) | KDM4EEDNRAMAT2ALMNAALDH1A1 | |
| SCHEMBL22760499 | 0.79 | NOTUM (0.37) | KDM4EEDNRACNR2LMNAALDH1A1 | |
| SCHEMBL22760495 | 0.77 | FOLH1 (0.37) | KDM4EEDNRACNR2FOLH1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |