SCHEMBL22760197

SCHEMBL22760197

CCOC(=O)c1c(OC2CCNC2)c2cc(Cl)c(Cl)cc2n1-c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.42
ALDH1A1 P00352 1/20 0.42
GAA P10253 1/20 0.42
MAT2A P31153 1/20 0.42
TP53 P04637 1/20 0.40
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
THRB P10828 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
PKM P14618 1/20 0.37
RECQL P46063 1/20 0.36
KDM4E B2RXH2 1/20 0.36
HTR1A P08908 1/20 0.36
SLC6A2 P23975 1/20 0.36
SLC6A4 P31645 1/20 0.36
SLC6A3 Q01959 1/20 0.36
SUCNR1 Q9BXA5 1/20 0.36
HSP90AB1 P08238 1/20 0.35
TOP2A P11388 1/20 0.35
MAPK8 P45983 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22747899 0.88 HTR1A (0.40) HTR1ASLC6A2SLC6A4SLC6A3SUCNR1
SCHEMBL22747874 0.84 MAPT (0.43) MAPTALDH1A1GAAMAT2ATP53
SCHEMBL22748436 0.79 MAPK8 (0.46) MAPTALDH1A1GAATP53MEN1
SCHEMBL22760562 0.76 ALDH1A1 (0.67) MAPTALDH1A1GAAMAT2ATP53
SCHEMBL22760558 0.73 ALDH1A1 (0.52) MAPTALDH1A1GAAMAT2ATP53
SCHEMBL22760097 0.72 CHRM4 (0.45) ALDH1A1MEN1KMT2ASLC6A2SLC6A4
SCHEMBL28556217 0.71 ALDH1A1 (0.43) MAPTALDH1A1GAAMAT2ATP53
SCHEMBL22760231 0.71 GAA (0.45) MAPTALDH1A1GAAMAT2ATP53
SCHEMBL22760423 0.71 MAPT (0.46) MAPTALDH1A1GAAMAT2ATP53
SCHEMBL22760422 0.68 ALDH1A1 (0.50) MAPTALDH1A1GAAMAT2ATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020244462-A1 INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF 中国药科大学 2020-12-10 WO disclosed