Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | INPPL1 | O15357 | 7/20 | 0.44 |
| ▸ | INPP5A | Q14642 | 4/20 | 0.44 |
| ▸ | INPP5B | P32019 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | IDUA | P35475 | 1/20 | 0.42 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18607330 | 0.84 | TSHR (0.49) | KDM4EUSP2ALDH1A1HPGDPDE3A | |
| SCHEMBL18607331 | 0.81 | CXCL8 (0.58) | KDM4EUSP2ALDH1A1HPGDPDE3A | |
| SCHEMBL20696700 | 0.80 | MTNR1A (0.45) | KDM4EUSP2ALDH1A1HPGDPDE3A | |
| SCHEMBL25833590 | 0.80 | L3MBTL1 (0.57) | KDM4EUSP2ALDH1A1HPGDPDE3A | |
| SCHEMBL21470214 | 0.77 | ALDH1A1 (0.41) | KDM4EUSP2ALDH1A1HPGDPDE3A | |
| SCHEMBL23692351 | 0.76 | ALDH1A1 (0.46) | KDM4EUSP2ALDH1A1HPGDPDE3A | |
| SCHEMBL1101447 | 0.75 | INPPL1 (0.53) | KDM4EUSP2ALDH1A1HPGDPDE3A | |
| SCHEMBL4957570 | 0.75 | INPPL1 (0.53) | KDM4EUSP2ALDH1A1HPGDPDE3A | |
| SCHEMBL29647909 | 0.75 | INPPL1 (0.53) | KDM4EUSP2ALDH1A1HPGDPDE3A | |
| SCHEMBL18498373 | 0.74 | INPPL1 (0.52) | KDM4EUSP2ALDH1A1HPGDPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344630-B1 | SUBSTITUTED 1,2-DIHYDRO-3H-PYRROLO[1,2-C]IMIDAZOL-3-ONE ANTIBACTERIAL COMPOUNDS | IDORSIA PHARMACEUTICALS LTD (CH) | 2020-12-09 | — | — | EP | disclosed |