SCHEMBL2276103

SCHEMBL2276103

O=C(Nc1cc(-c2ccc(O)cc2)ccc1C(=O)O)c1ccc([N+](=O)[O-])cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CD40 P25942 1/20 0.59
CD40LG P29965 1/20 0.59
ERO1A Q96HE7 1/20 0.57
KCNK2 O95069 1/20 0.55
KCNK10 P57789 1/20 0.55
KMT2A Q03164 3/20 0.54
AKR1C4 P17516 1/20 0.54
AKR1C3 P42330 1/20 0.54
AKR1C2 P52895 1/20 0.54
AKR1C1 Q04828 1/20 0.54
DHODH Q02127 1/20 0.52
MEN1 O00255 1/20 0.52
NPC1 O15118 1/20 0.52
ACLY P53396 1/20 0.51
HDAC2 Q92769 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.49
MAPT P10636 1/20 0.49
RAB9A P51151 1/20 0.49
ABCB1 P08183 2/20 0.48
ABCC1 P33527 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2276538 0.90 CD40 (0.65) CD40CD40LGERO1AKMT2AAKR1C4
SCHEMBL2272605 0.84 DHODH (0.73) KMT2ADHODHMEN1NPC1ACLY
SCHEMBL2031092 0.84 KCNK2 (0.64) CD40CD40LGERO1AKCNK2KCNK10
SCHEMBL2269733 0.84 ACLY (0.59) CD40CD40LGERO1AKCNK2KCNK10
SCHEMBL2274974 0.83 ACLY (0.67) KMT2ADHODHMEN1ACLYHDAC2
SCHEMBL2272122 0.82 DHODH (0.57) KCNK2KMT2ADHODHMEN1ACLY
SCHEMBL2273067 0.81 HDAC2 (0.76) CD40CD40LGERO1AKMT2AAKR1C4
SCHEMBL1309081 0.80 SMN1; SMN2 (0.70) CD40CD40LGERO1AKCNK2KCNK10
SCHEMBL2274927 0.80 ACLY (0.63) KCNK2KCNK10KMT2ADHODHMEN1
SCHEMBL2272704 0.80 ERO1A (0.53) CD40CD40LGERO1AKCNK2KCNK10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 CD40 2523/4885CD40LG 4744/4885ERO1A 1847/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.