SCHEMBL2276111

SCHEMBL2276111

O=C(Nc1cc(Oc2c(F)cccc2F)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PYGM P11217 4/20 0.55
PYGL P06737 2/20 0.55
MEN1 O00255 4/20 0.54
KMT2A Q03164 4/20 0.54
PKM P14618 3/20 0.54
TDP1 Q9NUW8 2/20 0.54
MAPT P10636 1/20 0.54
GRIK1 P39086 1/20 0.54
KCNK2 O95069 1/20 0.49
KCNK10 P57789 1/20 0.49
HPSE Q9Y251 1/20 0.49
RAB9A P51151 2/20 0.49
NPSR1 Q6W5P4 1/20 0.48
KDM4D Q6B0I6 1/20 0.48
KDM4C Q9H3R0 1/20 0.48
GALK1 P51570 1/20 0.47
CASP6 P55212 1/20 0.47
MCL1 Q07820 1/20 0.47
PLEC Q15149 1/20 0.47
SERPINE1 P05121 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2271217 0.88 PYGM (0.61) PYGMPYGLMEN1KMT2APKM
SCHEMBL2270688 0.87 PYGM (0.58) PYGMPYGLMEN1KMT2APKM
SCHEMBL2275435 0.86 PYGM (0.56) PYGMPYGLMEN1KMT2APKM
SCHEMBL2270449 0.85 PYGM (0.56) PYGMPYGLMEN1KMT2APKM
SCHEMBL2272615 0.85 PYGM (0.55) PYGMPYGLMEN1KMT2APKM
SCHEMBL2269555 0.85 HPSE (0.55) PYGMPYGLMEN1KMT2APKM
SCHEMBL2274811 0.85 PYGM (0.57) PYGMPYGLMEN1KMT2APKM
SCHEMBL2271588 0.84 SERPINE1 (0.64) PYGMPYGLMEN1KMT2APKM
SCHEMBL2271524 0.84 PYGM (0.56) PYGMPYGLMEN1KMT2APKM
SCHEMBL2270410 0.83 SERPINE1 (0.57) PYGMPYGLMEN1KMT2APKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 PYGM 1299/4885PYGL 1834/4885MEN1 3105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.