Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | CCR4 | P51679 | 2/20 | 0.33 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21387600 | 0.70 | CTPS1 (0.31) | — | |
| SCHEMBL21076824 | 0.70 | CTPS1 (0.48) | ATAD2LMNASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL21076850 | 0.68 | LCK (0.39) | ATAD2LMNASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL21077100 | 0.67 | CTPS1 (0.48) | ATAD2LMNASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL21076996 | 0.66 | CTPS1 (0.53) | ATAD2SMN1; SMN2KMT2ANPC1MEN1 | |
| SCHEMBL77452 | 0.62 | CCR4 (0.51) | ATAD2LMNASMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL21076997 | 0.61 | RAB9A (0.34) | ATAD2SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL2441700 | 0.60 | ATAD2 (0.40) | ATAD2LMNASMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL21181532 | 0.59 | KDM4E (0.45) | LMNAKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL15899105 | 0.59 | CCR4 (0.56) | ATAD2LMNASMN1; SMN2TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020245665-A1 | N-(4-(5-CHLOROPYRIDIN-3-YL)PHENYL)-2-(2-(CYCLOPROPANESULFONAMIDO)PYRIMIDIN-4-YL) BUTANAMIDE DERIVATIVES AND RELATED COMPOUNDS AS HUMAN CTPS1 INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | STEP PHARMA S.A.S. (FR) | 2020-12-10 | — | — | WO | disclosed |