SCHEMBL2276294

SCHEMBL2276294

O=C(Nc1cc(-c2ccccc2)ccc1C(=O)O)c1cc(-c2ccccc2)no1

nearest known ligand 0.57

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.57
KMT2A Q03164 4/20 0.57
ALDH1A1 P00352 1/20 0.57
ACLY P53396 10/20 0.55
SMN1; SMN2 Q16637 4/20 0.54
KDM4E B2RXH2 2/20 0.54
RAB9A P51151 2/20 0.53
RXFP1 Q9HBX9 1/20 0.53
HDAC1 Q13547 2/20 0.50
LMNA P02545 1/20 0.48
MAPT P10636 1/20 0.48
GFER P55789 1/20 0.47
DHODH Q02127 1/20 0.47
NPC1 O15118 1/20 0.45
CYP1A2 P05177 1/20 0.45
HPGD P15428 1/20 0.45
CYP2C19 P33261 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2273281 0.86 MEN1 (0.53) MEN1KMT2AALDH1A1ACLYSMN1; SMN2
SCHEMBL2272461 0.85 SMN1; SMN2 (0.55) MEN1KMT2AALDH1A1SMN1; SMN2KDM4E
SCHEMBL13901827 0.81 MEN1 (0.82) MEN1KMT2AALDH1A1SMN1; SMN2KDM4E
SCHEMBL13901584 0.78 MEN1 (0.82) MEN1KMT2AALDH1A1SMN1; SMN2KDM4E
SCHEMBL14205202 0.78 KMT2A (0.61) MEN1KMT2AALDH1A1SMN1; SMN2KDM4E
SCHEMBL2272656 0.78 HDAC1 (0.74) KMT2AALDH1A1ACLYSMN1; SMN2KDM4E
SCHEMBL6835662 0.78 MEN1 (0.52) MEN1KMT2AALDH1A1SMN1; SMN2KDM4E
SCHEMBL2270222 0.77 DHODH (0.77) MEN1KMT2AACLYKDM4ERAB9A
SCHEMBL2275453 0.77 ACLY (0.76) MEN1KMT2AACLYRAB9AHDAC1
SCHEMBL2275016 0.76 TP53 (0.58) ALDH1A1ACLYKDM4EHDAC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MEN1 3105/4885KMT2A 1669/4885ALDH1A1 645/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.