SCHEMBL2276609

SCHEMBL2276609

O=C(Nc1cc(-c2ccccc2O)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PKM P14618 3/20 0.59
KMT2A Q03164 3/20 0.59
MEN1 O00255 2/20 0.59
MAPT P10636 1/20 0.59
GRIK1 P39086 1/20 0.59
TDP1 Q9NUW8 1/20 0.59
HDAC1 Q13547 4/20 0.57
HDAC2 Q92769 2/20 0.57
ACLY P53396 2/20 0.56
DHODH Q02127 1/20 0.55
SERPINE1 P05121 2/20 0.51
HCAR2 Q8TDS4 1/20 0.49
KDM4D Q6B0I6 1/20 0.49
KDM4C Q9H3R0 1/20 0.49
HDAC3 O15379 1/20 0.49
PRSS12 P56730 1/20 0.48
SUCNR1 Q9BXA5 1/20 0.48
LTC4S Q16873 1/20 0.48
KCNMA1 Q12791 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27847469 0.91 ACLY (0.63) PKMKMT2AMEN1MAPTGRIK1
SCHEMBL2270359 0.85 MEN1 (0.57) PKMKMT2AMEN1MAPTGRIK1
SCHEMBL2275464 0.85 PRSS12 (0.65) PKMKMT2AMEN1MAPTGRIK1
SCHEMBL2270787 0.85 MEN1 (0.57) PKMKMT2AMEN1MAPTGRIK1
SCHEMBL14428374 0.84 HDAC1 (0.67) PKMKMT2AMEN1MAPTGRIK1
SCHEMBL12118197 0.84 ACLY (0.53) HDAC1HDAC2ACLYDHODHSERPINE1
SCHEMBL2275453 0.84 ACLY (0.76) PKMKMT2AMEN1MAPTGRIK1
SCHEMBL1316095 0.84 ACLY (0.52) HDAC1HDAC2ACLYDHODHSERPINE1
SCHEMBL2274974 0.83 ACLY (0.67) PKMKMT2AMEN1MAPTGRIK1
SCHEMBL2270510 0.82 MEN1 (0.54) PKMKMT2AMEN1MAPTGRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101094829-B novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO.,LTD. (JP) 2012-02-08 CN disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
CN-101094829-A Novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD (JP) 2007-12-26 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 PKM 2367/4885KMT2A 1669/4885MEN1 3105/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.