Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.78 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29484079 | 0.90 | MAPT (0.75) | MAPTALDH1A1MAPK1L3MBTL1LMNA | |
| SCHEMBL19286334 | 0.87 | MAPT (0.97) | MAPTALDH1A1MAPK1L3MBTL1LMNA | |
| SCHEMBL3614295 | 0.86 | MAPK1 (1.00) | MAPTALDH1A1MAPK1L3MBTL1DCTPP1 | |
| SCHEMBL3616361 | 0.85 | MAPT (1.00) | MAPTALDH1A1MAPK1L3MBTL1HTT | |
| SCHEMBL18036523 | 0.82 | MAPT (0.75) | MAPTALDH1A1MAPK1L3MBTL1LMNA | |
| SCHEMBL3616153 | 0.81 | MAPK1 (0.74) | MAPTALDH1A1MAPK1L3MBTL1HTT | |
| SCHEMBL3616157 | 0.81 | MAPK1 (0.74) | MAPTALDH1A1MAPK1L3MBTL1HTT | |
| SCHEMBL15340797 | 0.81 | MAPT (0.66) | MAPTALDH1A1MAPK1L3MBTL1LMNA | |
| SCHEMBL7809558 | 0.81 | MAPT (0.67) | MAPTALDH1A1MAPK1LMNAHTT | |
| SCHEMBL25313017 | 0.80 | MAPT (0.64) | MAPTALDH1A1MAPK1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250243168-A1 | ACETYL-COA SYNTHETASE 2 (ACSS2) INHIBITORS AND METHODS USING SAME | THE WISTAR INST (US) | 2025-07-31 | — | — | US | disclosed |
| US-12281084-B2 | Acetyl-CoA synthetase 2 (ACSS2) inhibitors and methods using same | THE WISTAR INSTITUTE (US) | 2025-04-22 | — | — | US | disclosed |
| US-20220281826-A1 | ACETYL-COA SYNTHETASE 2 (ACSS2) INHIBITORS AND METHODS USING SAME | THE WISTAR INSTITUTE | 2022-09-08 | — | — | US | disclosed |
| CN-114466840-A | acetyl-CoA synthetase 2(ACSS2) inhibitors and methods of use thereof | 威斯达研究所 | 2022-05-10 | — | — | CN | disclosed |
| EP-3983391-A1 | ACETYL-COA SYNTHETASE 2 (ACSS2) INHIBITORS AND METHODS USING SAME | The Wistar Institute (US) | 2022-04-20 | — | — | EP | disclosed |
| WO-2020252407-A1 | ACETYL-COA SYNTHETASE 2 (ACSS2) INHIBITORS AND METHODS USING SAME | THE WISTAR INSTITUTE (US) | 2020-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12281084-B2 | Acetyl-CoA synthetase 2 (ACSS2) inhibitors and methods using same | ACSS2, ACACB, ACACA | MAPT 4463/4885ALDH1A1 170/4885MAPK1 4052/4885 |
| US-20220281826-A1 | ACETYL-COA SYNTHETASE 2 (ACSS2) INHIBITORS AND METHODS USING SAME | ACSS2, ACACB, ACACA | MAPT 4463/4885ALDH1A1 170/4885MAPK1 4052/4885 |
| US-20250243168-A1 | ACETYL-COA SYNTHETASE 2 (ACSS2) INHIBITORS AND METHODS USING SAME | ACSS2, ACACB, ACACA | MAPT 4463/4885ALDH1A1 170/4885MAPK1 4052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.