Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22784355 | 0.80 | NOTUM (0.55) | MEN1KMT2ANOTUMTAAR1MAPT | |
| SCHEMBL13951292 | 0.77 | CHRM4 (0.52) | MEN1KMT2ANOTUMTAAR1MAPT | |
| SCHEMBL29561879 | 0.77 | RIPK1 (0.52) | MEN1KMT2ANOTUMTAAR1MAPT | |
| SCHEMBL22784252 | 0.76 | NOTUM (0.64) | MEN1KMT2ANOTUMTAAR1MAPT | |
| SCHEMBL10414143 | 0.75 | KEAP1 (0.76) | MEN1KMT2ANOTUMMAPTGAA | |
| SCHEMBL3717443 | 0.74 | PRMT5 (0.52) | MEN1KMT2ANOTUMTAAR1MAPT | |
| SCHEMBL303340 | 0.74 | NOTUM (0.67) | MEN1KMT2ANOTUMTAAR1MAPT | |
| SCHEMBL13487186 | 0.74 | NOTUM (0.67) | MEN1KMT2ANOTUMTAAR1MAPT | |
| SCHEMBL2628791 | 0.74 | P2RX4 (0.53) | MEN1KMT2ANOTUMTAAR1MAPT | |
| SCHEMBL22784271 | 0.73 | CHRM3 (0.58) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020252222-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2020-12-17 | — | — | WO | disclosed |