SCHEMBL2278451

SCHEMBL2278451

O=C(Nc1cc(CCc2ccc(O)cc2)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LTC4S Q16873 1/20 0.60
KMT2A Q03164 4/20 0.57
PKM P14618 3/20 0.57
MEN1 O00255 3/20 0.57
MAPT P10636 1/20 0.57
GRIK1 P39086 1/20 0.57
TDP1 Q9NUW8 1/20 0.57
PLK1 P53350 6/20 0.55
PLK3 Q9H4B4 4/20 0.55
MCL1 Q07820 1/20 0.55
BCL2A1 Q16548 1/20 0.55
HCAR2 Q8TDS4 2/20 0.52
DHODH Q02127 1/20 0.50
KDM4D Q6B0I6 1/20 0.48
KDM4C Q9H3R0 1/20 0.48
CCR5 P51681 1/20 0.47
ALDH1A1 P00352 1/20 0.47
SERPINE1 P05121 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2270925 0.96 PLK1 (0.57) LTC4SKMT2APKMMEN1MAPT
SCHEMBL2275929 0.93 KMT2A (0.62) LTC4SKMT2APKMMEN1MAPT
SCHEMBL2271080 0.88 MEN1 (0.56) LTC4SKMT2APKMMEN1MAPT
SCHEMBL2273122 0.88 PLK1 (0.57) LTC4SKMT2APKMMEN1MAPT
SCHEMBL2271236 0.88 PLK1 (0.60) LTC4SKMT2APKMMEN1MAPT
SCHEMBL2272409 0.88 PLK1 (0.63) LTC4SKMT2APKMMEN1MAPT
SCHEMBL2274939 0.86 PLK1 (0.55) LTC4SKMT2APKMMEN1MAPT
SCHEMBL2365188 0.86 PKM (0.54) LTC4SKMT2APKMMEN1MAPT
SCHEMBL2271421 0.85 DHODH (0.63) LTC4SKMT2APKMMEN1MAPT
SCHEMBL2274700 0.84 MEN1 (0.55) LTC4SKMT2APKMMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101094829-B novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO.,LTD. (JP) 2012-02-08 CN disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
CN-101094829-A Novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD (JP) 2007-12-26 CN disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 LTC4S 2518/4885KMT2A 1669/4885PKM 2367/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.